The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

TH Karlsen, N Sheron, S Zelber-Sagi, P Carrieri… - The Lancet, 2022 - thelancet.com
Executive summary Liver diseases have become a major health threat across Europe, and
the face of European hepatology is changing due to the cure of viral hepatitis C and the …

Targeting metabolic dysregulation for fibrosis therapy

X Zhao, JYY Kwan, K Yip, PP Liu, FF Liu - Nature reviews Drug …, 2020 - nature.com
Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …

AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease

ME Rinella, BA Neuschwander-Tetri, MS Siddiqui… - Hepatology, 2023 - journals.lww.com
Abbreviations: AASLD, American Association for the Study of Liver Diseases; AI, artificial
intelligence; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUROC …

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis–2021 update

A Berzigotti, E Tsochatzis, J Boursier, L Castera… - Journal of …, 2021 - Elsevier
Non-invasive tests are increasingly being used to improve the diagnosis and
prognostication of chronic liver diseases across aetiologies. Herein, we provide the latest …

Accuracy of FibroScan controlled attenuation parameter and liver stiffness measurement in assessing steatosis and fibrosis in patients with nonalcoholic fatty liver …

PJ Eddowes, M Sasso, M Allison, E Tsochatzis… - Gastroenterology, 2019 - Elsevier
Background & Aims We estimated the accuracy of FibroScan vibration-controlled transient
elastography controlled attenuation parameter (CAP) and liver stiffness measurement …

[HTML][HTML] Prospective evaluation of a primary care referral pathway for patients with non-alcoholic fatty liver disease

A Srivastava, R Gailer, S Tanwar, P Trembling… - Journal of …, 2019 - Elsevier
Background & Aims The development of non-invasive liver fibrosis tests may enable earlier
identification of patients with non-alcoholic fatty liver disease (NAFLD) requiring referral to …

[PDF][PDF] Population screening for liver fibrosis: toward early diagnosis and intervention for chronic liver diseases

P Ginès, L Castera, F Lammert, I Graupera… - …, 2022 - Wiley Online Library
Cirrhosis, highly prevalent worldwide, develops after years of hepatic inflammation
triggering progressive fibrosis. Currently, the main etiologies of cirrhosis are non‐alcoholic …

Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus

G Targher, A Lonardo, CD Byrne - Nature reviews endocrinology, 2018 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and diabetes mellitus are common diseases that
often coexist and might act synergistically to increase the risk of hepatic and extra-hepatic …

Implementation of a liver health check in people with type 2 diabetes

KWM Abeysekera, L Valenti, Z Younossi… - The Lancet …, 2024 - thelancet.com
As morbidity and mortality related to potentially preventable liver diseases are on the rise
globally, early detection of liver fibrosis offers a window of opportunity to prevent disease …

Barriers to surveillance for hepatocellular carcinoma in a multicenter cohort

ND Parikh, N Tayob, T Al-Jarrah, J Kramer… - JAMA network …, 2022 - jamanetwork.com
Importance Hepatocellular carcinoma (HCC) surveillance is underused in clinical practice,
which may be owing to patient and clinician barriers. Objective To characterize HCC …