The multifaceted role of reactive oxygen species in tumorigenesis
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …
various normal cellular functions including cellular growth, differentiation, senescence …
[HTML][HTML] Catalase, a remarkable enzyme: targeting the oldest antioxidant enzyme to find a new cancer treatment approach
C Glorieux, PB Calderon - Biological chemistry, 2017 - degruyter.com
This review is centered on the antioxidant enzyme catalase and will present different
aspects of this particular protein. Among them: historical discovery, biological functions …
aspects of this particular protein. Among them: historical discovery, biological functions …
[PDF][PDF] The role of Nrf2 in oxidative stress-induced endothelial injuries
B Chen, Y Lu, Y Chen, J Cheng - J Endocrinol, 2015 - scholar.archive.org
Endothelial dysfunction is an important risk factor for cardiovascular disease, and it
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …
Potential applications of NRF2 inhibitors in cancer therapy
E Panieri, L Saso - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms
against exogenous or endogenous stressors. Indeed, by increasing the expression of …
against exogenous or endogenous stressors. Indeed, by increasing the expression of …
The Nrf2/HO‐1 axis in cancer cell growth and chemoresistance
AL Furfaro, N Traverso, C Domenicotti… - Oxidative medicine …, 2016 - Wiley Online Library
The transcription factor, nuclear factor erythroid 2 p45‐related factor 2 (Nrf2), acts as a
sensor of oxidative or electrophilic stresses and plays a pivotal role in redox homeostasis …
sensor of oxidative or electrophilic stresses and plays a pivotal role in redox homeostasis …
Potential applications of NRF2 modulators in cancer therapy
The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …
An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy
The Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating a
wide array of genes for antioxidant and detoxification enzymes in response to oxidative and …
wide array of genes for antioxidant and detoxification enzymes in response to oxidative and …
Helicobacter pylori outer membrane vesicles induce astrocyte reactivity through nuclear factor-κappa B activation and cause neuronal damage in vivo in a murine …
E Palacios, L Lobos-González, S Guerrero… - Journal of …, 2023 - Springer
Abstract Background Helicobacter pylori (Hp) infects the stomach of 50% of the world's
population. Importantly, chronic infection by this bacterium correlates with the appearance of …
population. Importantly, chronic infection by this bacterium correlates with the appearance of …
The role of natural products in revealing NRF2 function
Covering: up to 2020 The transcription factor NRF2 is one of the body's major defense
mechanisms, driving transcription of> 300 antioxidant response element (ARE)-regulated …
mechanisms, driving transcription of> 300 antioxidant response element (ARE)-regulated …
Tumour microenvironment stress promotes the development of drug resistance
Multi-drug resistance (MDR) is a leading cause of cancer-related death, and it continues to
be a major barrier to cancer treatment. The tumour microenvironment (TME) has proven to …
be a major barrier to cancer treatment. The tumour microenvironment (TME) has proven to …