Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney

H Bayır, SJ Dixon, YY Tyurina, JA Kellum… - Nature Reviews …, 2023 - nature.com
Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …

Sepsis associated acute kidney injury

JT Poston, JL Koyner - Bmj, 2019 - bmj.com
Sepsis is defined as organ dysfunction resulting from the host's deleterious response to
infection. One of the most common organs affected is the kidneys, resulting in sepsis …

The interplay of oxidative stress and ROS scavenging: antioxidants as a therapeutic potential in sepsis

S Kumar, J Saxena, VK Srivastava, S Kaushik, H Singh… - Vaccines, 2022 - mdpi.com
Oxidative stress resulting from the disproportion of oxidants and antioxidants contributes to
both physiological and pathological conditions in sepsis. To combat this, the antioxidant …

Empagliflozin mitigates endothelial inflammation and attenuates endoplasmic reticulum stress signaling caused by sustained glycocalyx disruption

MA Campeau, RL Leask - Scientific Reports, 2022 - nature.com
The disruption of the endothelial cell (EC) glycocalyx (GCX) leads to cellular dysfunction
promoting inflammation and cardiovascular disease progression. Recent studies have …

Effect of N‐acetylcysteine on antioxidant defense, oxidative modification, and salivary gland function in a rat model of insulin resistance

P Żukowski, M Maciejczyk, J Matczuk… - Oxidative Medicine …, 2018 - Wiley Online Library
Oxidative stress plays a crucial role in the salivary gland dysfunction in insulin resistance
(IR). It is not surprising that new substances are constantly being sought that will protect …

N‐Acetylcysteine Attenuates Cisplatin‐Induced Acute Kidney Injury by Inhibiting the C5a Receptor

S Huang, J You, K Wang, Y Li, Y Zhang… - BioMed Research …, 2019 - Wiley Online Library
N‐acetylcysteine has been widely used as a nutritional supplement and drug in humans for
its antioxidant properties. The complement activation fragment C5a is a strong …

[PDF][PDF] Rationale and evidence for the adjunctive use of N-acetylcysteine in multidrug-resistant infections.

A Oliva, L Pallecchi, GM Rossolini… - European Review for …, 2023 - europeanreview.org
Bacterial multidrug resistance has been a serious issue for healthcare systems in recent
decades, responsible for many infections and deaths. Due to the increasing incidence of …

[HTML][HTML] N-acetylcysteine Ameliorates Vancomycin-induced Nephrotoxicity by Inhibiting Oxidative Stress and Apoptosis in the in vivo and in vitro Models

P Yu, J Luo, H Song, T Qian, X He, J Fang… - … Journal of Medical …, 2022 - ncbi.nlm.nih.gov
Background: Oxidative stress-related apoptosis is considered as the key mechanism
implicated in the pathophysiology of nephrotoxicity with vancomycin (VCM) therapy. We …

The effect of N-acetylcysteine on respiratory enzymes, ADP/ATP ratio, glutathione metabolism, and nitrosative stress in the salivary gland mitochondria of insulin …

A Zalewska, I Szarmach, M Żendzian-Piotrowska… - Nutrients, 2020 - mdpi.com
This is the first study to assess the effect of N-acetylcysteine (NAC) on the mitochondrial
respiratory system, as well as free radical production, glutathione metabolism, nitrosative …

[PDF][PDF] Therapeutic potential of N-acetyl cysteine (NAC) in preventing cytokine storm in COVID-19: review of current evidence.

RR Mohanty, BM Padhy, S Das… - European Review for …, 2021 - europeanreview.org
Since November 2019, SARS Coronavirus 2 disease (COVID-19) pandemic has spread
through more than 195 nations worldwide. Though the coronavirus infection affects all age …