A large power generation facility is a complex multi-criteria system associated with
multivariate couplings, high dependency, and non-linearity among the operating variables …

Highlights•Highlight CMC strategies to address the increasing rAAV vector demand.•Outline
solutions in the areas of cell line development and upstream processing to increase AAV …

Nanotechnology facilitated the development and scalable commercialization of many SARS-
CoV-2 vaccines. However, the supply chains underpinning vaccine manufacturing have …

Reinforcement Learning (RL) has recently received significant attention from the process
systems engineering and control communities. Recent works have investigated the …

As caretakers of the hematopoietic system, hematopoietic stem cells assure a lifelong supply
of differentiated populations that are responsible for critical bodily functions, including …

Realisation of pharmaceutical product and production systems capable of delivering product
customisation cost-effectively is essential for adding value to patients and society through …

Recent clinical outcomes of Advanced Therapy Medicinal Products (ATMPs) highlight
promising opportunities in the prevention and cure of life threatening diseases. ATMP …

Abstract Advanced Therapy Medicinal Products (ATMPs) are an emerging class of
therapeutic the development of which is primarily based on genetically engineering genes …

Personalised medicine (PM) is a new area of healthcare that has shown promising results in
offering treatments for rare and advanced stage diseases. Nonetheless, their supply chain …

Gene therapy products have tremendous therapeutic potential for indications such as cancer
and even curative potential for some genetic diseases. Most of today's gene therapy …