In this article we review the value and utility of the minipig as an animal model in regulatory
toxicity testing. Our review is based on detailed consideration of the comparative biology of …

Introduction This article gives an overview of the drug metabolism and disposition (ADME)
characteristics of the most common non-rodent species used in toxicity testing of drugs …

Subcutaneous (SC) delivery is a common route of administration for therapeutic monoclonal
antibodies (mAbs) with pharmacokinetic (PK)/pharmacodynamic (PD) properties requiring …

Abstract (Mini) pigs have proven to be a valuable animal model in nutritional, metabolic and
cardiovascular research and in some other biomedical research areas (toxicology …

Animals' tail posture and motion play an important role in communication, amongst others. In
domestic pigs, the debate around tail docking and tail biting has made the tail an important …

As part of the RETHINK European FP6 Project an overview of the acceptability and
usefulness of minipigs has been carried out in the regulatory arenas of human and …

While developments in gynecologic health research continue advancing, relatively few
groups specifically focus on vaginal tissue research for areas like wound healing, device …

There is currently no objective and validated quality of life assessment tool available to
assess the quality of life of domestic dogs in kennels. This study aimed to develop a …

Over the past 3 decades minipigs have moved from being an obscure alternative to dogs
and nonhuman primates to being a standard animal model in regulatory toxicity studies. This …

Pigs are commonly kept in intensive farming systems. Their use as model animals in
biomedical research has increased. Both conditions may impact upon their welfare. Recent …