The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

NADPH oxidases of the Nox family are important enzymatic sources of reactive oxygen
species (ROS). Numerous homologue-specific mechanisms control the activity of this …

The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase
(G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in …

atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …

Hypertension is a leading risk factor for disease burden worldwide. The kidneys, which have
a high specific metabolic rate, play an essential role in the long-term regulation of arterial …

Significance: The molecular machinery regulating autophagy has started becoming
elucidated, and a number of studies have undertaken the task to determine the role of …

Reactive oxygen species (ROS) are cellular signals but also disease triggers; their relative
excess (oxidative stress) or shortage (reductive stress) compared to reducing equivalents …

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen
species-generating enzymes that broadly and specifically regulate redox-sensitive …

Reactive oxygen species (ROS) produced by nicotinamide adenine dinucleotide phosphate
oxidase (NOX) play a key role in liver injury and fibrosis. Previous studies demonstrated that …

Virally induced liver cancer usually evolves over long periods of time in the context of a
strongly oxidative microenvironment, characterized by chronic liver inflammation and …