Late-life depression is associated with significant cognitive impairment. Meta-analyses
showed that depression is associated with an increased risk for Alzheimer's disease (AD) …

Background In recent years, we have accomplished a deeper understanding about the
pathophysiology of major depressive disorder (MDD). Nevertheless, this improved …

BACKGROUND: Ketamine has rapid antidepressant effects lasting as long as 1 week in
patients with major depressive disorder (MDD) and bipolar depression (BD). Ketamine is …

A critical review of the limited available evidence and the authors' experience and judgment
are used to summarize the role of cytochrome P450 (CYP) genetic variants in the …

Cytochrome P450 enzymes (CYPs) metabolize many drugs that act on the central nervous
system (CNS), such as antidepressants and antipsychotics; drugs of abuse; endogenous …

Cytochrome (CYP) P450 enzymes have a primary role in antidepressant metabolism and
variants in these polymorphic genes are targets for pharmacogenetic investigation. This is …

Introduction: Millions of people worldwide suffer from depression, but despite advances in
pharmacological therapies, many patients do not experience symptomatic remission or …

The detrimental effects of steroid-mimics are well known but investigations on non-steroid
pharmaceuticals are less common. In addition, most behavioral studies do not examine the …

Major depressive disorder (MDD) is a heritable disease with a heavy personal and socio-
economic burden. Antidepressants of different classes are prescribed to treat MDD, but …

Major depressive disorder (MDD) is an emergent cause of personal and socioeconomic
burden, both for the high prevalence of the disorder and the unsatisfying response rate of …