The role of non-invasive respiratory support (high-flow nasal oxygen and noninvasive
ventilation) in the management of acute hypoxemic respiratory failure and acute respiratory …

The severe acute respiratory syndrome coronavirus-2 emerged as a serious human
pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The …

Mechanical ventilation can cause acute diaphragm atrophy and injury, and this is associated
with poor clinical outcomes. Although the importance and impact of lung-protective …

Mechanical ventilation may have adverse effects on both the lung and the diaphragm. Injury
to the lung is mediated by excessive mechanical stress and strain, whereas the diaphragm …

Neural respiratory drive, ie, the activity of respiratory centres controlling breathing, is an
overlooked physiologic variable which affects the pathophysiology and the clinical outcome …

Respiratory drive, the intensity of the respiratory center's output, determines the effort
exerted in each breath. The increasing awareness of the adverse effects of both strong and …

Patients with severe lung injury usually have a high respiratory drive, resulting in intense
inspiratory effort that may even worsen lung damage by several mechanisms gathered …

Rationale: High-flow nasal cannula (HFNC) and helmet noninvasive ventilation (NIV) are
used for the management of acute hypoxemic respiratory failure. Objectives: Physiological …

Several mechanisms of diaphragm muscle injury (myotrauma) can result in ventilator-
induced diaphragm dysfunction, including ventilator over-assistance, under-assistance …

Background Excessive respiratory muscle effort during mechanical ventilation may cause
patient self-inflicted lung injury and load-induced diaphragm myotrauma, but there are no …