Nucleation, stabilization, and disassembly of branched actin networks
AM Gautreau, FE Fregoso, G Simanov… - Trends in cell …, 2022 - cell.com
Arp2/3 complex is an actin filament nucleation and branching machinery conserved in all
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …
Actin dynamics in cell migration
Cell migration is an essential process, both in unicellular organisms such as amoeba and as
individual or collective motility in highly developed multicellular organisms like mammals. It …
individual or collective motility in highly developed multicellular organisms like mammals. It …
Mechanisms of actin disassembly and turnover
Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …
their biological roles. Once assembled, these filamentous networks are either maintained in …
The Arp2/3 regulatory system and its deregulation in cancer
N Molinie, A Gautreau - Physiological reviews, 2018 - journals.physiology.org
The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …
branched actin networks. When activated, the Arp2/3 complex contributes the actin …
Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction
The actin-related protein (Arp) 2/3 complex nucleates branched actin filament networks
pivotal for cell migration, endocytosis and pathogen infection. Its activation is tightly …
pivotal for cell migration, endocytosis and pathogen infection. Its activation is tightly …
HIV-1 diverts cortical actin for particle assembly and release
Enveloped viruses assemble and bud from the host cell membranes. Any role of cortical
actin in these processes have often been a source of debate. Here, we assessed if cortical …
actin in these processes have often been a source of debate. Here, we assessed if cortical …
Regeneration of actin filament branches from the same Arp2/3 complex
F Ghasemi, LY Cao, M Mladenov, B Guichard… - Science …, 2024 - science.org
Branched actin filaments are found in many key cellular structures. Branches are nucleated
by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to …
by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to …
The stabilization of Arp2/3 complex generated actin filaments
The Arp2/3 complex, which generates both branched but also linear actin filaments via
activation of SPIN90, is evolutionarily conserved in eukaryotes. Several factors regulate the …
activation of SPIN90, is evolutionarily conserved in eukaryotes. Several factors regulate the …
[HTML][HTML] Role of actin-binding proteins in the regulation of cellular mechanics
AV Vakhrusheva, AV Murashko, ES Trifonova… - European Journal of …, 2022 - Elsevier
The viscoelastic parameters of the cell can report on the cell state, cellular processes and
diseases. Cell mechanics strongly rely on the properties of the cytoskeleton, an important …
diseases. Cell mechanics strongly rely on the properties of the cytoskeleton, an important …
[HTML][HTML] Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling
J Qi, W Cheng, Z Gao, Y Chen, ML Shipton… - Biomedicine & …, 2023 - Elsevier
The antifungal drug itraconazole has been repurposed to anti-angiogenic agent, but the
mechanisms of action have been elusive. Here we report that itraconazole disrupts focal …
mechanisms of action have been elusive. Here we report that itraconazole disrupts focal …