Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes, which
affects over 90% of the diabetic patients. Although pain is one of the main symptoms of …

The voltage-gated sodium channel NaV1. 7 is preferentially expressed in peripheral somatic
and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons …

Painful peripheral neuropathy often occurs without apparent underlying cause. Gain-of-
function variants of sodium channel Nav1. 7 have recently been found in∼ 30% of cases of …

Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …

Sodium channel Nav1. 9 is expressed in peripheral nociceptive neurons, as well as visceral
afferents, and has been shown to act as a threshold channel. Painful peripheral neuropathy …

The discovery of genetic variants that substantially alter an individual's perception of pain
has led to a step-change in our understanding of molecular events underlying the detection …

Reprogramming somatic cells from one cell fate to another can generate specific neurons
suitable for disease modeling. To maximize the utility of patient-derived neurons, they must …

Human studies have firmly implicated voltage-gated sodium channels in human pain
disorders, and targeted and massively parallel genomic sequencing is beginning to be used …

Symptomatic treatment of neuropathic pain in small fibre neuropathy is often disappointing.
The finding of voltage-gated sodium channel mutations in small fibre neuropathy (with …