Inhibition of protein aggregation and endoplasmic reticulum stress as a targeted therapy for α-synucleinopathy
N Siwecka, K Saramowicz, G Galita… - Pharmaceutics, 2023 - mdpi.com
α-synuclein (α-syn) is an intrinsically disordered protein abundant in the central nervous
system. Physiologically, the protein regulates vesicle trafficking and neurotransmitter release …
system. Physiologically, the protein regulates vesicle trafficking and neurotransmitter release …
The immune system in Parkinson's disease: what we know so far
Parkinson's disease (PD) is characterised neuropathologically by the degeneration of
dopaminergic neurons in the ventral midbrain, the accumulation of α-synuclein (α-syn) …
dopaminergic neurons in the ventral midbrain, the accumulation of α-synuclein (α-syn) …
Comparison of Alternative pre-mRNA Splicing and Gene Expression Patterns in Midbrain Lineage Cells Carrying Familial Parkinson's Disease Mutations
YJ Lee, K Syed, O Busquets, H Li, J Dunnack… - bioRxiv, 2024 - biorxiv.org
Parkinson's disease (PD) is a devastating neurodegenerative disorder, with both genetic
and environmental causes. Human genetic studies have identified∼ 20 inherited familial …
and environmental causes. Human genetic studies have identified∼ 20 inherited familial …