Mitochondrial permeability transition pore (mPTP)-dependent cell death is a form of necrotic
cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is …

Mitochondria are important generators of energy, providing ATP through oxidative
phosphorylation. However, mitochondria also monitor complex information from the …

Cardiac contractility is mediated by a variable flux in intracellular calcium (Ca 2+), thought to
be integrated into mitochondria via the mitochondrial calcium uniporter (MCU) channel to …

In the heart, augmented Ca 2+ fluxing drives contractility and ATP generation through
mitochondrial Ca 2+ loading. Pathologic mitochondrial Ca 2+ overload with ischemic injury …

The global burden of neurodegenerative diseases is alarmingly increasing in parallel to the
aging of population. Although the molecular mechanisms leading to neurodegeneration are …

Background and purpose: The mitochondrial permeability transition pore (mPTP), an energy‐
dissipating channel activated by calcium, contributes to reperfusion damage by depolarizing …

The field of mitochondrial ion channels underwent a rapid development during the last
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …

It has been documented that Ca 2+ overload and increased production of reactive oxygen
species play a significant role in reperfusion injury (RI) of cardiomyocytes …

Background—Impairment of intracellular Ca2+ homeostasis and mitochondrial function has
been implicated in the development of cardiomyopathy. Mitochondrial Ca2+ uptake is …

Enhanced reactive oxygen species (ROS) at the beginning of reperfusion activated signal
transducer and activator of transcription 3 (STAT3) in intermittent hypobaric hypoxia (IHH) …