Coronaviruses are pathogens with a serious impact on human and animal health. They
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …

The outbreak of COVID-19, the pandemic disease caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has spurred an intense search for treatments by the …

SARS-CoV-2 has currently precipitated the COVID-19 global health crisis. We developed a
medium-throughput drug-screening system and identified a small-molecule library of 34 of …

Abstract Positive-sense RNA ((+) RNA) viruses such as hepatitis C virus exploit host cells by
subverting host proteins, remodelling subcellular membranes, co-opting and modulating …

Hepatitis C virus (HCV) is a major causative agent of chronic liver disease in humans. To
gain insight into host factor requirements for HCV replication, we performed a siRNA screen …

The global coronavirus disease-19 (COVID-19) has affected more than 140 million and
killed more than 3 million people worldwide as of April 20, 2021. The novel human severe …

Hepatitis C virus (HCV) chronically infects 3% of the world's population, and complications
from HCV are the leading indication for liver transplantation. Given the need for better anti …

Hepatitis C virus (HCV) infection is a major cause of end-stage liver disease and a leading
indication for liver transplantation. Current therapy fails in many instances and is associated …

Hepatitis C virus (HCV) reorganizes cellular membranes to establish sites of replication. The
required host pathways and the mechanism of cellular membrane reorganization are poorly …

Hepatitis C virus (HCV) enters hepatocytes following a complex set of receptor interactions,
culminating in internalization via clathrin-mediated endocytosis. However, aside from …