[HTML][HTML] Discovery and development of safe-in-man broad-spectrum antiviral agents

PI Andersen, A Ianevski, H Lysvand… - International Journal of …, 2020 - Elsevier
Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-
specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases …

Coronavirus COVID-19: Available free literature provided by various companies, journals and organizations around the world

S Nadeem - Journal of Ongoing Chemical Research, 2020 - dergipark.org.tr
Human history is observing a very strange time fighting an invisible enemy; the novel COVID-
19 coronavirus. Initially observed in the Wuhan province of China, now fastly spreading …

Preparing for the next viral threat with broad-spectrum antivirals

M Karim, CW Lo, S Einav - The Journal of Clinical …, 2023 - Am Soc Clin Investig
There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …

Doxycycline-encapsulated solid lipid nanoparticles as promising tool against Brucella melitensis enclosed in macrophage: a pharmacodynamics study on J774A.1 …

SM Hosseini, R Abbasalipourkabir, FA Jalilian… - … Resistance & Infection …, 2019 - Springer
Background Brucellosis is a zoonotic disease caused by Brucella species. It has been
estimated that more than 500,000 new cases of Brucellosis occur annually all around the …

Zooming in on common immune evasion mechanisms of pathogens in phagolysosomes: potential broad-spectrum therapeutic targets against infectious diseases

A Selvapandiyan, N Puri, P Kumar… - FEMS Microbiology …, 2023 - academic.oup.com
The intracellular viral, bacterial, or parasitic pathogens evade the host immune challenges to
propagate and cause fatal diseases. The microbes overpower host immunity at various …

[HTML][HTML] Pomegranate peel induced biogenic synthesis of silver nanoparticles and their multifaceted potential against intracellular pathogen and cancer

AA Khan, AM Alanazi, N Alsaif, TA Wani… - Saudi Journal of …, 2021 - Elsevier
In the field of nano-biotechnology, silver nanoparticles (AgNPs) share a status of high repute
owing to their remarkable medicinal values. Biological synthesis of environment-friendly …

Metformin and Covid-19: focused review of mechanisms and current literature suggesting benefit

S Ibrahim, JR Lowe, CT Bramante, S Shah… - Frontiers in …, 2021 - frontiersin.org
Metformin is the first-line medication for type 2 diabetes, but it also has a long history of
improved outcomes in infectious diseases, such as influenza, hepatitis C, and in-vitro assays …

Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment

SY Pu, F Xiao, S Schor, E Bekerman, F Zanini… - Antiviral research, 2018 - Elsevier
There is an urgent need for strategies to combat dengue virus (DENV) infection; a major
global threat. We reported that the cellular kinases AAK1 and GAK regulate intracellular …

Induction of Programmed Cell Death in Acanthamoeba culbertsoni by the Repurposed Compound Nitroxoline

RL Rodríguez-Expósito, I Sifaoui, M Reyes-Batlle… - Antioxidants, 2023 - mdpi.com
Acanthamoeba is a ubiquitous genus of amoebae that can act as opportunistic parasites in
both humans and animals, causing a variety of ocular, nervous and dermal pathologies …

Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention

JD Adderley, S John von Freyend, SA Jackson… - Nature …, 2020 - nature.com
Intracellular pathogens mobilize host signaling pathways of their host cell to promote their
own survival. Evidence is emerging that signal transduction elements are activated in a …