Cholinergic changes in Lewy body disease: implications for presentation, progression and subtypes

N Okkels, MJ Grothe, JP Taylor, SG Hasselbalch… - Brain, 2024 - academic.oup.com
Cholinergic degeneration is significant in Lewy body disease, including Parkinson's
disease, dementia with Lewy bodies, and isolated REM sleep behavior disorder. Extensive …

[HTML][HTML] Degeneration of cholinergic white matter pathways and nucleus basalis of Meynert in individuals with objective subtle cognitive impairment

T Qiu, H Hong, Q Zeng, X Luo, X Wang, X Xu, F Xie… - Neurobiology of …, 2023 - Elsevier
We evaluated alterations in the nucleus basalis of Meynert (NBM) volume and integrity of
cholinergic white matter pathways in objective subtle cognitive impairment (Obj-SCI) …

Implications of fitting a two-compartment model in single-shell diffusion MRI

JA Chad, N Sochen, JJ Chen… - Physics in Medicine & …, 2023 - iopscience.iop.org
It is becoming increasingly common for studies to fit single-shell diffusion MRI data to a two-
compartment model, which comprises a hindered cellular compartment and a freely diffusing …

[HTML][HTML] Effect of cerebral small vessel disease on the integrity of cholinergic system in mild cognitive impairment patients: a longitudinal study

T Qiu, H Hong, Q Zeng, X Xu, Y Wang, L Zhu… - Journal of …, 2024 - Springer
We aimed to investigate the effect of cerebral small vessel disease (SVD) on cholinergic
system integrity in mild cognitive impairment (MCI) patients. Nucleus basalis of Meynert …

White Matter Microstructure Analysis in Subjective Memory Complaints and Cognitive Impairment: Insights from Diffusion Kurtosis Imaging and Free-Water DTI

M Bergamino, E Keeling, M McElvogue… - Journal of …, 2024 - content.iospress.com
Background: Dementia is characterized by a cognitive decline in memory and other domains
that lead to functional impairments. As people age, subjective memory complaints (SMC) …

Free-Water Imaging of the Nucleus Basalis of Meynert in Patients With Idiopathic REM Sleep Behavior Disorder and Parkinson Disease

D Zhang, L Zhou, C Lu, T Feng, J Liu, T Wu - Neurology, 2024 - AAN Enterprises
Background and Objectives Cognitive impairments are common in idiopathic REM sleep
behavior disorder (iRBD), in which the cholinergic degeneration of nucleus basalis of …

[HTML][HTML] Increased Extracellular Water in Normal-Appearing White Matter in Patients with Cerebral Small Vessel Disease

S Man, S Chen, Z Xu, H Zhang, Z Cao - Journal of Integrative …, 2024 - imrpress.com
Background: Microcirculatory variations have been observed in the normal-appearing white
matter (NAWM) of individuals affected by cerebral small vessel disease (CSVD). These …

Neuroimaging modalities in the detection of Alzheimer's disease-associated biomarkers

C Dang, Y Wang, Q Li, Y Lu - Psychoradiology, 2023 - academic.oup.com
Alzheimer's disease (AD) is the most common cause of dementia. Neuropathological
changes in AD patients occur up to 10–20 years before the emergence of clinical symptoms …

Cerebrovascular co-pathology and cholinergic white matter pathways along the Lewy body continuum

C Jerele, A Tzortzakakis, M Nemy, A Rennie, J Arranz… - 2024 - researchsquare.com
Background: Dementia with Lewy Bodies (DLB) often presents with cholinergic
degeneration and varying degrees of cerebrovascular disease (CVD). Radiological methods …