Abstract Box C/D and H/ACA RNPs are essential ribonucleoprotein particles that are found
throughout both eukaryotes [small nucleolar RNPs (snoRNPs)] and archaea [snoRNP‐like …

Box C/D and box H/ACA snoRNAs are abundant non-coding RNAs that localize in the
nucleolus and mostly function as guides for nucleotide modifications. While a large pool of …

The cell nucleus contains dozens of subcompartments that separate biochemical processes
into confined spaces. Cajal bodies (CBs) were discovered more than 100 years ago, but …

The nuclear cap–binding complex (CBC) stimulates multiple steps in several RNA
maturation pathways, but how it functions in humans is incompletely understood. For small …

Aside from nucleoli, Cajal bodies (CBs) are the best-characterized organelles of mammalian
cell nuclei. Like nucleoli, CBs concentrate ribonucleoproteins (RNPs), in particular …

Biogenesis of the human telomerase RNA (hTR) involves a complex series of
posttranscriptional modifications, including hypermethylation of the 5′ mono …

Non-coding RNAs (ncRNAs) are important regulatory molecules involved in various
physiological and pathological cellular processes. Small nucleolar RNAs (snoRNAs) …

Abstract Tri methylguanosine synthase 1 (TGS1) is the enzyme that hyper methylates the
hallmark 7-methyl-guanosine cap (m7G-cap) appended to the transcription start site of …

Termination of RNA polymerase II (RNAPII) transcription is a fundamental step of gene
expression that is critical for determining the borders between genes. In budding yeast …

Box C/D small nucleolar RNAs (C/D snoRNAs) represent an ancient family of small non-
coding RNAs that are classically viewed as housekeeping guides for the 2′-O-methylation …