Endocrine disrupting chemicals and reproductive health in boys and men

W Rodprasert, J Toppari, HE Virtanen - Frontiers in endocrinology, 2021 - frontiersin.org
Male reproductive health has declined as indicated by increasing rates of cryptorchidism, ie,
undescended testis, poor semen quality, low serum testosterone level, and testicular cancer …

Disruption in thyroid signaling pathway: a mechanism for the effect of endocrine-disrupting chemicals on child neurodevelopment

A Ghassabian, L Trasande - Frontiers in endocrinology, 2018 - frontiersin.org
Thyroid hormones are crucial in normal brain development. Transient and mild thyroid
hormone insufficiency in pregnancy is also associated with impaired neurodevelopment in …

Risk to human health related to the presence of perfluoroalkyl substances in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2020 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific evaluation on the risks to
human health related to the presence of perfluoroalkyl substances (PFAS s) in food. Based …

Application of the key characteristics of carcinogens to per and polyfluoroalkyl substances

AM Temkin, BA Hocevar, DQ Andrews… - International journal of …, 2020 - mdpi.com
Per-and polyfluoroalkyl substances (PFAS) constitute a large class of environmentally
persistent chemicals used in industrial and consumer products. Human exposure to PFAS is …

Prenatal perfluoroalkyl substances exposure and maternal sex steroid hormones across pregnancy

Z Rivera-Núñez, CW Kinkade, L Khoury, J Brunner… - Environmental …, 2023 - Elsevier
Background Poly-and perfluoroalkyl substances (PFAS) are ubiquitous and persistent
environmental contaminants that may act as endocrine disruptors in utero, but the specific …

Androgens and the masculinization programming window: human–rodent differences

RM Sharpe - Biochemical Society Transactions, 2020 - portlandpress.com
Human male reproductive disorders are common and may have a fetal origin—the testicular
dysgenesis syndrome (TDS) hypothesis. In rats, experimentally induced TDS disorders …

Prenatal exposure to perfluoroalkyl substances and birth outcomes in a Spanish birth cohort

CB Manzano-Salgado, M Casas… - Environment …, 2017 - Elsevier
Background Prenatal perfluorooctanoate (PFOA) exposure has been associated with
reduced birth weight but maternal glomerular filtration rate (GFR) may attenuate this …

Serum perfluorooctanoic acid and birthweight: an updated meta-analysis with bias analysis

K Steenland, V Barry, D Savitz - Epidemiology, 2018 - journals.lww.com
Background: A recent meta-analysis of 15 studies found a change in birthweight of− 12.8 g
(95% CI=− 23.1,− 2.38) per ng/ml PFOA in maternal or cord blood and− 27.1 g (− 50.6,− 3.6) …

Association between exposure to per-and polyfluoroalkyl substances and birth outcomes: a systematic review and meta-analysis

SY Gui, YN Chen, KJ Wu, W Liu, WJ Wang… - Frontiers in Public …, 2022 - frontiersin.org
Background A large body of emerging evidence suggests that per-and polyfluoroalkyl
substances (PFAS) affect birth outcomes in various pathways, but the evidence is …

Exposure to perfluoroalkyl substances during fetal life and pubertal development in boys and girls from the Danish National Birth Cohort

A Ernst, N Brix, LLB Lauridsen, J Olsen… - Environmental …, 2019 - ehp.niehs.nih.gov
Background: It remains unsettled whether prenatal exposure to perfluoroalkyl substances
(PFASs) affects human reproductive health through potential endocrine disruption …