Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and
neuropeptides. In this review, we examine the variability in the individual peptides produced …

The pituitary adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and
stress response and is thus the major component of the hypothalamo–pituitary–adrenal axis …

The standard model of adrenocortical zonation holds that the three main zones,
glomerulosa, fasciculata, and reticularis each have a distinct function, producing …

The purpose of this article is to review fundamentals in adrenal gland histophysiology. Key
findings regarding the important signaling pathways involved in the regulation of …

Adrenal cortical carcinomas (ACC) are rare but aggressive tumours associated with poor
prognosis. The two most frequent alterations in ACC in patients are overexpression of the …

Introduction Adrenocorticotropic hormone (ACTH) is produced from proopiomelanocortin,
which is predominantly synthetized in the corticotroph and melanotroph cells of the anterior …

The participation of aberrant receptors and intra-adrenal ACTH in hyperplastic tissue are
considered mechanisms that regulate hypercortisolism in PMAH. Additionally, germline …

This review summarizes key knowledge regarding the development, growth, and growth
disorders of the adrenal cortex from a molecular perspective. The adrenal gland consists of …

Pro-opiomelanocortin (POMC) is a polypeptide precursor known to yield biologically active
peptides related to a range of functions. These active peptides include the …

Background New drugs for adrenocortical carcinoma (ACC) are needed because most
patients undergo rapid disease progression despite surgery and adjuvant therapy with …