Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

▪ Abstract Spines are neuronal protrusions, each of which receives input typically from one
excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling …

Down syndrome (DS) is a neurological disorder with multiple immune-related symptoms;
however, crosstalk between the CNS and peripheral immune system remains unexplored …

Down syndrome is the most common form of intellectual disability and results from one of the
most complex genetic perturbations that is compatible with survival, trisomy 21. The study of …

Ts65Dn mice, a model for Down syndrome, have excessive inhibition in the dentate gyrus, a
condition that could compromise synaptic plasticity and mnemonic processing. We show that …

Although many genetic disorders are characterized by cognitive failure during development,
there is little insight into the neurobiological basis for the abnormalities. Down syndrome …

A consistent feature of neurons in patients with mental retardation is abnormal dendritic
structure and/or alterations in dendritic spine morphology. Deficits in the regulation of the …

Over-inhibition is thought to be one of the underlying causes of the cognitive deficits in
Ts65Dn mice, the most widely used model of Down syndrome. We found a direct link …

Abstract The Ts65Dn mouse is a genetic model for Down syndrome. Although this mouse
shows abnormalities in cognitive function that implicate hippocampus as well as marked …

Down syndrome (DS) is the most common genetic cause of mental disability. Based on the
homology of Hsa21 and the murine chromosomes Mmu16, Mmu17 and Mmu10, several …