Targeting Sphingosine-1-Phosphate Signaling in Breast Cancer
M Nagahashi, Y Miyoshi - International Journal of Molecular Sciences, 2024 - mdpi.com
In recent years, newly emerging therapies, such as immune checkpoint inhibitors and
antibody-drug conjugates, have further improved outcomes for breast cancer patients …
antibody-drug conjugates, have further improved outcomes for breast cancer patients …
S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway
Z Zheng, YZ Zeng, K Ren, X Zhu, Y Tan, Y Li… - International …, 2019 - Elsevier
Inflammation-induced lymphangiogenesis is a widely accepted concept. However, most of
the inflammatory factors and their related mechanisms have not been clarified. It has been …
the inflammatory factors and their related mechanisms have not been clarified. It has been …
Short periods of hypoxia upregulate sphingosine kinase 1 and increase vasodilation of arteries to sphingosine 1-phosphate (S1P) via S1P3
Sphingosine kinase [(SK), isoforms SK1 and SK2] catalyzes the formation of the bioactive
lipid, sphingosine 1-phosphate (S1P). This can be exported from cells and bind to S1P …
lipid, sphingosine 1-phosphate (S1P). This can be exported from cells and bind to S1P …
Acute hypobaric hypoxia-mediated biochemical/metabolic shuffling and differential modulation of S1PR-SphK in cardiac and skeletal muscles
Aim: High altitude exposure alters biochemical, metabolic, and physiological features of
heart and skeletal muscles, and hence has pathological consequences in these tissues …
heart and skeletal muscles, and hence has pathological consequences in these tissues …