In this review, we summarize the multiple functions of NQO1, its established roles in redox
processes and potential roles in redox control that are currently emerging. NQO1 has …

NQO1 is one of the two major quinone reductases in mammalian systems. It is highly
inducible and plays multiple roles in cellular adaptation to stress. A prevalent polymorphic …

For many years, the ubiquitin-26S proteasome degradation pathway was considered the
primary route for proteasomal degradation. However, it is now becoming clear that proteins …

NAD (P) H: quinone oxidoreductase (NQO) is an antioxidant flavoprotein that catalyzes the
reduction of highly reactive quinone metabolites by employing NAD (P) H as an electron …

NQO1 can be induced by multiple forms of stress including oxidative stress. NQO1 is a
pleiotropic enzyme and consideration of some of the known endogenous substrates and …

PGC-1α is a key transcription coactivator regulating energy metabolism in a tissue-specific
manner. PGC-1α expression is tightly regulated, it is a highly labile protein, and it interacts …

Summary NAD (P) H: quinone-oxidoreductase-1 (NQO1) is a cytosolic enzyme that
catalyzes the reduction of various quinones using flavin adenine dinucleotide (FAD) as a …

The p53 tumor suppressor is embedded in a large gene network controlling diverse cellular
and organismal phenotypes. Multiple signaling pathways converge onto p53 activation …

HIF-1α is a master regulator of oxygen homeostasis involved in different stages of cancer
development. Thus, HIF-1α inhibition represents an interesting target for anti-cancer therapy …

The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a master regulator
of a battery of antioxidant and detoxificant genes with cytoprotective function. Since Nrf2 …