International Union of Pharmacology. XV. Subtypes of γ-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function
EA Barnard, P Skolnick, RW Olsen, H Mohler… - Pharmacological …, 1998 - ASPET
This article does not aim to review in detail the properties of-aminobutyric acidA (GABAA) b
receptors, because recent accounts of that topic are available. In this same journal, a review …
receptors, because recent accounts of that topic are available. In this same journal, a review …
Hooked on benzodiazepines: GABAA receptor subtypes and addiction
Benzodiazepines are widely used clinically to treat anxiety and insomnia. They also induce
muscle relaxation, control epileptic seizures, and can produce amnesia. Moreover …
muscle relaxation, control epileptic seizures, and can produce amnesia. Moreover …
Cryo-EM structures reveal native GABAA receptor assemblies and pharmacology
Type A γ-aminobutyric acid receptors (GABAARs) are the principal inhibitory receptors in the
brain and the target of a wide range of clinical agents, including anaesthetics, sedatives …
brain and the target of a wide range of clinical agents, including anaesthetics, sedatives …
Local GABA circuit control of experience-dependent plasticity in developing visual cortex
Sensory experience in early life shapes the mammalian brain. An impairment in the activity-
dependent refinement of functional connections within developing visual cortex was …
dependent refinement of functional connections within developing visual cortex was …
Tonically active GABAA receptors: modulating gain and maintaining the tone
A Semyanov, MC Walker, DM Kullmann… - Trends in neurosciences, 2004 - cell.com
GABA A receptors not only respond to the local release of GABA from presynaptic terminals,
but can also mediate a persistent 'tonic current'. This reflects the activation of high-affinity …
but can also mediate a persistent 'tonic current'. This reflects the activation of high-affinity …
Recurrent collateral connections of striatal medium spiny neurons are disrupted in models of Parkinson's disease
S Taverna, E Ilijic, DJ Surmeier - Journal of Neuroscience, 2008 - Soc Neuroscience
The principal neurons of the striatum, GABAergic medium spiny neurons (MSNs), are
interconnected by local recurrent axon collateral synapses. Although critical to many striatal …
interconnected by local recurrent axon collateral synapses. Although critical to many striatal …
Molecular and cellular mechanisms of pharmacoresistance in epilepsy
S Remy, H Beck - Brain, 2006 - academic.oup.com
Epilepsy is a common and devastating neurological disorder. In many patients with epilepsy,
seizures are well-controlled with currently available anti-epileptic drugs (AEDs), but a …
seizures are well-controlled with currently available anti-epileptic drugs (AEDs), but a …
GABA uptake regulates cortical excitability via cell type–specific tonic inhibition
A Semyanov, MC Walker, DM Kullmann - Nature neuroscience, 2003 - nature.com
GABAA receptors can mediate both'phasic'synaptic inhibition and a persistent'tonic'form of
signaling. We show that, in the presence of intact GABA uptake, guinea pig hippocampal …
signaling. We show that, in the presence of intact GABA uptake, guinea pig hippocampal …
The cellular, molecular and ionic basis of GABAA receptor signalling
GABA A receptors mediate fast synaptic inhibition in the CNS. Whilst this is undoubtedly
true, it is a gross oversimplification of their actions. The receptors themselves are diverse …
true, it is a gross oversimplification of their actions. The receptors themselves are diverse …
Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by γ-aminobutyric acidA receptors in hippocampal …
γ-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter, activates a persistent
low amplitude tonic current in several brain regions in addition to conventional synaptic …
low amplitude tonic current in several brain regions in addition to conventional synaptic …