This article does not aim to review in detail the properties of-aminobutyric acidA (GABAA) b
receptors, because recent accounts of that topic are available. In this same journal, a review …

Benzodiazepines are widely used clinically to treat anxiety and insomnia. They also induce
muscle relaxation, control epileptic seizures, and can produce amnesia. Moreover …

Type A γ-aminobutyric acid receptors (GABAARs) are the principal inhibitory receptors in the
brain and the target of a wide range of clinical agents, including anaesthetics, sedatives …

Sensory experience in early life shapes the mammalian brain. An impairment in the activity-
dependent refinement of functional connections within developing visual cortex was …

GABA A receptors not only respond to the local release of GABA from presynaptic terminals,
but can also mediate a persistent 'tonic current'. This reflects the activation of high-affinity …

The principal neurons of the striatum, GABAergic medium spiny neurons (MSNs), are
interconnected by local recurrent axon collateral synapses. Although critical to many striatal …

Epilepsy is a common and devastating neurological disorder. In many patients with epilepsy,
seizures are well-controlled with currently available anti-epileptic drugs (AEDs), but a …

GABAA receptors can mediate both'phasic'synaptic inhibition and a persistent'tonic'form of
signaling. We show that, in the presence of intact GABA uptake, guinea pig hippocampal …

GABA A receptors mediate fast synaptic inhibition in the CNS. Whilst this is undoubtedly
true, it is a gross oversimplification of their actions. The receptors themselves are diverse …

γ-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter, activates a persistent
low amplitude tonic current in several brain regions in addition to conventional synaptic …