Inflammatory bowel diseases (IBDs) in humans are complex chronic inflammatory disorders
of largely unknown cause. Several mouse models that in some respects resemble human …

Today's computational, experimental, and observational sciences rely on computations that
involve many related tasks. The success of a scientific mission often hinges on the computer …

The largest-scale high-performance (HPC) systems are stretching parallel file systems to
their limits in terms of aggregate bandwidth and numbers of clients. To further sustain the …

Visualization and analysis tools, techniques, and algorithms have undergone a rapid
evolution in recent decades to accommodate explosive growth in data size and complexity …

Applications running on leadership platforms are more and more bottlenecked by storage
input/output (I/O). In an effort to combat the increasing disparity between I/O throughput and …

Emerging high-performance distributed computing environments are enabling new end-to-
end formulations in science and engineering that involve multiple interacting processes and …

With the onset of extreme-scale computing, I/O constraints make it increasingly difficult for
scientists to save a sufficient amount of raw simulation data to persistent storage. One …

Significant challenges exist for achieving peak or even consistent levels of performance
when using IO systems at scale. They stem from sharing IO system resources across the …

Peta-scale scientific applications running on High End Computing (HEC) platforms can
generate large volumes of data. For high performance storage and in order to be useful to …

Unmatched computation and storage performance in new HPC systems have led to a
plethora of I/O optimizations ranging from application-side collective I/O to network and disk …