Animal models of intestinal inflammation: new insights into the molecular pathogenesis and immunotherapy of inflammatory bowel disease

S Wirtz, MF Neurath - International journal of colorectal disease, 2000 - Springer
Inflammatory bowel diseases (IBDs) in humans are complex chronic inflammatory disorders
of largely unknown cause. Several mouse models that in some respects resemble human …

The future of scientific workflows

E Deelman, T Peterka, I Altintas… - … Journal of High …, 2018 - journals.sagepub.com
Today's computational, experimental, and observational sciences rely on computations that
involve many related tasks. The success of a scientific mission often hinges on the computer …

On the role of burst buffers in leadership-class storage systems

N Liu, J Cope, P Carns, C Carothers… - 2012 IEEE 28th …, 2012 - ieeexplore.ieee.org
The largest-scale high-performance (HPC) systems are stretching parallel file systems to
their limits in terms of aggregate bandwidth and numbers of clients. To further sustain the …

[图书][B] High performance visualization: Enabling extreme-scale scientific insight

EW Bethel, H Childs, C Hansen - 2012 - books.google.com
Visualization and analysis tools, techniques, and algorithms have undergone a rapid
evolution in recent decades to accommodate explosive growth in data size and complexity …

Hello ADIOS: the challenges and lessons of developing leadership class I/O frameworks

Q Liu, J Logan, Y Tian, H Abbasi… - Concurrency and …, 2014 - Wiley Online Library
Applications running on leadership platforms are more and more bottlenecked by storage
input/output (I/O). In an effort to combat the increasing disparity between I/O throughput and …

Dataspaces: an interaction and coordination framework for coupled simulation workflows

C Docan, M Parashar, S Klasky - Proceedings of the 19th ACM …, 2010 - dl.acm.org
Emerging high-performance distributed computing environments are enabling new end-to-
end formulations in science and engineering that involve multiple interacting processes and …

Combining in-situ and in-transit processing to enable extreme-scale scientific analysis

JC Bennett, H Abbasi, PT Bremer… - SC'12: Proceedings …, 2012 - ieeexplore.ieee.org
With the onset of extreme-scale computing, I/O constraints make it increasingly difficult for
scientists to save a sufficient amount of raw simulation data to persistent storage. One …

Managing variability in the IO performance of petascale storage systems

J Lofstead, F Zheng, Q Liu, S Klasky… - SC'10: Proceedings …, 2010 - ieeexplore.ieee.org
Significant challenges exist for achieving peak or even consistent levels of performance
when using IO systems at scale. They stem from sharing IO system resources across the …

PreDatA–preparatory data analytics on peta-scale machines

F Zheng, H Abbasi, C Docan, J Lofstead… - … on Parallel & …, 2010 - ieeexplore.ieee.org
Peta-scale scientific applications running on High End Computing (HEC) platforms can
generate large volumes of data. For high performance storage and in order to be useful to …

CALCioM: Mitigating I/O interference in HPC systems through cross-application coordination

M Dorier, G Antoniu, R Ross, D Kimpe… - 2014 IEEE 28th …, 2014 - ieeexplore.ieee.org
Unmatched computation and storage performance in new HPC systems have led to a
plethora of I/O optimizations ranging from application-side collective I/O to network and disk …