The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Fasting of mice is a common procedure performed in association with many different types of
experiments mainly in order to reduce variability in investigatory parameters or to facilitate …

Diabetes mellitus is prevalent among women of reproductive age, and many women are left
undiagnosed or untreated. Gestational diabetes has profound and enduring effects on the …

Acetate is a major nutrient that supports acetyl-coenzyme A (Ac-CoA) metabolism and thus
lipogenesis and protein acetylation. However, its source is unclear. Here, we report that …

Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic
acid (TCA)-cycle carbon, but whether the same metabolic phenotype is found in tumors is …

Metformin, the universal first-line treatment for type 2 diabetes, exerts its therapeutic glucose-
lowering effects by inhibiting hepatic gluconeogenesis. However, the primary molecular …

Most patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed with advanced
disease and survive less than 12 months. PDAC has been linked with obesity and glucose …

Metformin is considered to be one of the most effective therapeutics for treating type 2
diabetes because it specifically reduces hepatic gluconeogenesis without increasing insulin …

Obesity affects> 600 million people worldwide, a staggering number that appears to be on
the rise. One of the lesser known consequences of obesity is its deleterious effects on …

The pyruvate kinase M2 isoform (PKM2) is expressed in cancer and plays a role in
regulating anabolic metabolism. To determine whether PKM2 is required for tumor formation …