Gut microbiota and oleoylethanolamide in the regulation of intestinal homeostasis

C De Filippo, A Costa, MV Becagli… - Frontiers in …, 2023 - frontiersin.org
A vast literature strongly suggests that the endocannabinoid (eCB) system and related
bioactive lipids (the paracannabinoid system) contribute to numerous physiological …

Endocannabinoid-related molecules predict the metabolic efficacy of GLP-1 receptor agonism in humans with obesity

I Matias, EW Lehmann, P Zizzari, S Byberg… - Journal of …, 2024 - Springer
Objective N-acylethanolamines (NAEs) include endocannabinoid (EC) and EC-related
molecules that impact the anti-obesity and anti-diabetic efficacy of glucagon-like peptide-1 …

Transcriptomic (DNA Microarray) and Metabolome (LC-TOF-MS) Analyses of the Liver in High-Fat Diet Mice after Intranasal Administration of GALP (Galanin-like …

F Takenoya, J Shibato, M Yamashita, A Kimura… - International Journal of …, 2023 - mdpi.com
The aim of this research was to test the efficacy and potential clinical application of
intranasal administration of galanin-like peptide (GALP) as an anti-obesity treatment under …

Pharmacological Inhibition of N-Acylethanolamine Acid Amidase (NAAA) Mitigates Intestinal Fibrosis Through Modulation of Macrophage Activity

MF Nanì, E Pagano, P De Cicco… - Journal of Crohn's …, 2024 - academic.oup.com
Abstract Background and Aims Intestinal fibrosis, a frequent complication of inflammatory
bowel disease, is characterized by stricture formation with no pharmacological treatment to …

Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood

L Lin, KM Jung, HL Lee, J Le, G Colleluori, C Wood… - Cell Metabolism, 2023 - cell.com
One of cannabis' most iconic effects is the stimulation of hedonic high-calorie eating—the"
munchies"—yet habitual cannabis users are, on average, leaner than non-users. We asked …

Oleoylethanolamide improves energy disposal in a cellular model of Alzheimer's disease

A Quentin, F Dieter, M Reutzel… - Journal of Mitochondria …, 2024 - Taylor & Francis
Oleoylethanolamide (OEA) is an endogenous lipid mediator which is being discussed as a
weight-loss drug for obesity. In addition to its homoeostatic functions, OEA has …

Compositions and methods for treating non-alcoholic steatohepatitis

M Williams - US Patent 11,744,808, 2023 - Google Patents
Abstract Cepharanthine, Repirinast, Ifenoprodil Hemitartrate, Bromantane, Actarit,
Lobenzarit, Irsogladine, Istradefylline, Trapadil, Bemithyl, and are used for treating or …