Dendritic cells (DCs) contribute a small fraction of the tumor microenvironment but are
emerging as an essential antitumor component based on their ability to foster T cell …

The theory that cancer-associated fibroblasts (CAFs) are immunosuppressive cells has
prevailed throughout the past decade. However, recent high-throughput, high-resolution …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory
cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet …

The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a
complex ecosystem that drives tumor progression; however, in-depth single cell …

Despite the increasing interest in targeting stromal elements of the tumor microenvironment,
we still face tremendous challenges in developing adequate therapeutics to modify the …

Endometriosis is characterized by the growth of endometrial-like tissue outside the uterus. It
affects many women during their reproductive age, causing years of pelvic pain and …

Cancer-associated fibroblasts (CAFs) are generally associated with poor clinical outcome.
CAFs support tumor growth in a variety of ways and can suppress antitumor immunity and …

The organization of immune cells in human tumors is not well understood. Immunogenic
tumors harbor spatially localized multicellular 'immunity hubs' defined by expression of the T …

Metastasis still represents the primary cause of cancer morbidity and mortality worldwide.
Chemokine signalling contributes to the overall process of cancer growth and metastasis …

The term fibroblast has been used generally to describe spindle-shaped stromal cells of
mesenchymal origin that produce extracellular matrix, establish tissue structure, and form …