Mitochondrial dysfunction has been regarded as a hallmark of diabetic cardiomyopathy. In
addition to their canonical metabolic actions, mitochondria influence various other aspects of …

Mitochondria are critical multifunctional organelles in cells that generate power, produce
reactive oxygen species, and regulate cell survival. Mitochondria that are dysfunctional are …

Traditionally, mitochondria are known as" the powerhouse of the cell," responsible for
energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …

The skin is the largest organ of the human body and the first line of defense against
environmental hazards. Many factors, including internal factors such as natural aging and …

Mitophagy must be carefully regulated to ensure that cells maintain appropriate numbers of
functional mitochondria. The SCFFBXL4 ubiquitin ligase complex suppresses mitophagy by …

Diabetic cardiomyopathy is a chronic cardiovascular complication caused by diabetes that is
characterized by changes in myocardial structure and function, ultimately leading to heart …

Neurodegenerative diseases, characterized by progressive neuronal dysfunction and loss,
pose significant health challenges. Glutamate accumulation contributes to neuronal cell …

Recent studies based on animal models of various neurological disorders have indicated
that mitophagy, a selective autophagy that eliminates damaged and superfluous …

Traumatic brain injury (TBI), a kind of external trauma‐induced brain function alteration, has
posed a financial burden on the public health system. TBI pathogenesis involves a …

Mitophagy induction upon mitochondrial stress is critical for maintaining mitochondrial
homeostasis and cellular function. Here, we found that Mst1/2 (Stk3/4), key regulators of the …