Rho‐associated kinase (Rho‐kinase/ROCK/ROK) is an effector of the small GTPase Rho
and belongs to the AGC family of kinases. Rho‐kinase has pleiotropic functions including …

Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

Axonal regeneration in the peripheral nervous system is greatly supported by Schwann cells
(SCs). After nerve injury, SCs dedifferentiate to a progenitor‐like state and efficiently guide …

Highlights•Growth cone formation requires a precise actin and microtubule organization.•
Modulating cytoskeleton stability affects growth cone formation and axon elongation.• …

Cofilin and actin-depolymerizing factor (ADF) are actin-binding proteins that play an
essential role in regulating actin filament dynamics and reorganization by stimulating the …

Recent studies indicate the actin and microtubule cytoskeletons are a final common target of
many signaling cascades that influence the developing neuron. Regulation of polymer …

The actin-binding proteins of the actin-depolymerisation factor (ADF)/cofilin family were first
described more than three decades ago, but research on these proteins still occupies a front …

The LIM kinase family consists of just two members: LIM kinase 1 (LIMK1) and LIM kinase 2
(LIMK2). With uniquely organised signalling domains, LIM kinases are regulated by several …

Transforming growth factor-β (TGFβ) signalling, particularly signalling from the bone
morphogenetic protein (BMP) members of this protein family, is crucial for the development …

Cofilin is a ubiquitous actin-binding factor required for the reorganization of actin filaments in
eukaryotes. The dephosphorylation of cofilin enables its actin severing and depolymerizing …