Computationally driven discovery in coagulation

KG Link, MT Stobb, DM Monroe… - … , and vascular biology, 2021 - Am Heart Assoc
Bleeding frequency and severity within clinical categories of hemophilia A are highly
variable and the origin of this variation is unknown. Solving this mystery in coagulation …

Untangling the complexity of blood coagulation network: use of computational modelling in pharmacology and diagnostics

AM Shibeko, MA Panteleev - Briefings in Bioinformatics, 2016 - academic.oup.com
Blood coagulation is a complex biochemical network that plays critical roles in haemostasis
(a physiological process that stops bleeding on injury) and thrombosis (pathological vessel …

Application of smooth particle hydrodynamics method for modelling blood flow with thrombus formation

M Al-Saad, CA Suarez, A Obeidat… - … in Engineering & …, 2020 - ingentaconnect.com
Thrombosis plays a crucial role in atherosclerosis or in haemostasis when a blood vessel is
injured. This article focuses on using a meshless particle-based Lagrangian numerical …

A step toward balance: thrombin generation improvement via procoagulant factor and antithrombin supplementation

AY Mitrophanov, F Szlam, RM Sniecinski… - Anesthesia & …, 2016 - journals.lww.com
BACKGROUND: The use of prothrombin complex concentrates in trauma-and surgery-
induced coagulopathy is complicated by the possibility of thromboembolic events. To …

A mathematical model for in vitro coagulation of blood: role of platelet count and inhibition

M Susree, M Anand - Sādhanā, 2017 - Springer
A mechanistic model including the role of platelets is proposed for clot formation and growth
in plasma in vitro. Initiation of clot formation is by the addition of tissue factor, and initiation …

Continuous modeling of arterial platelet thrombus formation using a spatial adsorption equation

ES Babushkina, NM Bessonov, FI Ataullakhanov… - PloS one, 2015 - journals.plos.org
In this study, we considered a continuous model of platelet thrombus growth in an arteriole.
A special model describing the adhesion of platelets in terms of their concentration was …

An individualized blood coagulation model to predict INR therapeutic range during warfarin treatment

A Bouchnita, K Bouzaachane… - … Modelling of Natural …, 2016 - mmnp-journal.org
Deep venous thrombosis (DVT) is characterized by formation of blood clot within a deep
vein. The resulting thrombus can partially or completely block blood circulation. It can also …

Blood flow simulation using smooth particle hydrodynamics

M Al-Saad - 2017 - orca.cardiff.ac.uk
Blood flow rheology is a complex phenomenon, and the study of blood flow in the human
body system under normal and pathological conditions are considered to be of great …