A comprehensive review on MAPK: a promising therapeutic target in cancer

C Braicu, M Buse, C Busuioc, R Drula, D Gulei… - Cancers, 2019 - mdpi.com
The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch
from extracellular signals to intracellular responses. Alterations of signaling cascades are …

Immunotherapy in the treatment of metastatic melanoma: current knowledge and future directions

M Ralli, A Botticelli, IC Visconti… - Journal of …, 2020 - Wiley Online Library
Melanoma is one of the most immunologic malignancies based on its higher prevalence in
immune‐compromised patients, the evidence of brisk lymphocytic infiltrates in both primary …

2D and 3D electrospinning technologies for the fabrication of nanofibrous scaffolds for skin tissue engineering: A review

A Keirouz, M Chung, J Kwon… - Wiley …, 2020 - Wiley Online Library
This review provides insights into the current advancements in the field of electrospinning,
focusing on its applications for skin tissue engineering. Furthermore, it reports the …

CSC radioresistance: a therapeutic challenge to improve radiotherapy effectiveness in cancer

MA Olivares-Urbano, C Griñán-Lisón, JA Marchal… - Cells, 2020 - mdpi.com
Radiotherapy (RT) is a modality of oncologic treatment that can be used to treat
approximately 50% of all cancer patients either alone or in combination with other treatment …

Nitrogen-containing heterocycles as anticancer agents: An overview

DK Lang, R Kaur, R Arora, B Saini… - Anti-Cancer Agents in …, 2020 - ingentaconnect.com
Background: Cancer is spreading all over the world, and it is becoming the leading cause of
major deaths. Today's most difficult task for every researcher is to invent a new drug that can …

Molecular targets of tyrosine kinase inhibitors in thyroid cancer

P Fallahi, SM Ferrari, MR Galdiero, G Varricchi… - Seminars in cancer …, 2022 - Elsevier
Thyroid cancer (TC) is the eighth most frequently diagnosed cancer worldwide with a rising
incidence in the past 20 years. Surgery is the primary strategy of therapy for patients with …

Glucose oxidase–polymer nanogels for synergistic cancer-starving and oxidation therapy

W Zhao, J Hu, W Gao - ACS applied materials & interfaces, 2017 - ACS Publications
Glucose oxidase (GOX) can convert glucose into gluconic acid and hydrogen peroxide
(H2O2), which is potentially useful for synergistic cancer-starving and oxidation therapy …

Framework nucleic acid immune adjuvant for transdermal delivery based chemo-immunotherapy for malignant melanoma treatment

F Shen, L Sun, L Wang, R Peng, C Fan, Z Liu - Nano Letters, 2022 - ACS Publications
Despite the tremendous progresses of cancer immunotherapy, its current clinical responses
rate in melanoma remains to be improved. Here, we have reported a skin penetrating …

[HTML][HTML] Novel treatments for anaplastic thyroid carcinoma

SM Ferrari, G Elia, F Ragusa, I Ruffilli, C La Motta… - Gland …, 2020 - ncbi.nlm.nih.gov
Anaplastic thyroid cancer (ATC) is one of the deadliest human cancers and it is less than 2%
of thyroid carcinomas (TCs). The standard treatment of ATC includes surgical debulking …

Clinical development of talimogene laherparepvec (T-VEC): a modified herpes simplex virus type-1–derived oncolytic immunotherapy

KJ Harrington, I Puzanov, JR Hecht… - Expert review of …, 2015 - Taylor & Francis
Tumor immunotherapy is emerging as a promising new treatment option for patients with
cancer. T-VEC is an intralesional oncolytic virus therapy based on a modified herpes …