Tissue-engineered heart valves have been proposed by physicians and scientists alike to
be the ultimate solution for treating valvular heart disease. Rather than replacing a diseased …

Surgical replacement of diseased heart valves by mechanical and tissue valve substitutes is
now commonplace and enhances survival and quality of life for many patients. However …

L. Yaskanin (65) Prior Publication Data US 2005/O11391. 0 A1 May 26, 2005(57)
ABSTRACT The present invention comprises a percutaneously implant Related US …

Substitute heart valves composed of human or animal tissues have been used since the
early 1960s, when aortic valves obtained fresh from human cadavers were transplanted to …

Written by more than 400 subject experts representing diverse academic and applied
domains, this multidisciplinary resource surveys the vanguard of biomaterials and …

Bovine pericardium is a collagenous tissue commonly used as a natural biomaterial in the
fabrication of cardiovascular devices. For tissue engineering purposes, this xenogeneic …

The native human heart valve leaflet contains a layered microstructure comprising a
hierarchical arrangement of collagen, elastin, proteoglycans and various cell types. Here …

Cell colonization is an important in a wide variety of biological processes and applications
including vascularization, wound healing, tissue engineering, stem cell differentiation, and …

Valvular heart disease has recently become an increasing public health concern due to the
high prevalence of valve degeneration in aging populations. For patients with severely …

Atherosclerosis is a leading cause of death worldwide, and its mechanisms are still unclear.
However, various animal models have significantly advanced our understanding of the …