Apoptosis and clearance of apoptotic cells

S Nagata - Annual review of immunology, 2018 - annualreviews.org
The human body generates 10–100 billion cells every day, and the same number of cells
die to maintain homeostasis in our body. Cells infected by bacteria or viruses also die. The …

Immunogenic and tolerogenic cell death

DR Green, T Ferguson, L Zitvogel… - Nature Reviews …, 2009 - nature.com
The immune system is routinely exposed to dead cells during normal cell turnover, injury
and infection. Mechanisms must exist to discriminate between different forms of cell death to …

Autoimmunity and the clearance of dead cells

S Nagata, R Hanayama, K Kawane - Cell, 2010 - cell.com
To maintain organismal homeostasis, phagocytes engulf dead cells, which are recognized
as dead by virtue of a characteristic" eat me" signal exposed on their surface. The dead cells …

The phagocytic code regulating phagocytosis of mammalian cells

TOJ Cockram, JM Dundee, AS Popescu… - Frontiers in …, 2021 - frontiersin.org
Mammalian phagocytes can phagocytose (ie eat) other mammalian cells in the body if they
display certain signals, and this phagocytosis plays fundamental roles in development, cell …

[HTML][HTML] 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance

S Uderhardt, M Herrmann, OV Oskolkova… - Immunity, 2012 - cell.com
Noninflammatory clearance of apoptotic cells (ACs) is crucial to maintain self-tolerance.
Here, we have reported a role for the enzyme 12/15-lipoxygenase (12/15-LO) as a central …

The role of phosphatidylserine recognition receptors in multiple biological functions

MB Naeini, V Bianconi, M Pirro, A Sahebkar - Cellular & molecular biology …, 2020 - Springer
Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis.
Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase …

Disturbances of apoptotic cell clearance in systemic lupus erythematosus

WH Shao, PL Cohen - Arthritis research & therapy, 2011 - Springer
Systemic lupus erythematosus is a multifactorial autoimmune disease with an as yet
unknown etiopathogenesis. It is widely thought that self-immunization in systemic lupus is …

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction

M Nakaya, K Watari, M Tajima… - The Journal of …, 2017 - Am Soc Clin Investig
Myocardial infarction (MI) results in the generation of dead cells in the infarcted area. These
cells are swiftly removed by phagocytes to minimize inflammation and limit expansion of the …

Lactadherin and clearance of platelet-derived microvesicles

SK Dasgupta, H Abdel-Monem… - Blood, The Journal …, 2009 - ashpublications.org
The transbilayer movement of phosphatidylserine from the inner to the outer leaflet of the
membrane bilayer during platelet activation is associated with the release of procoagulant …

milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation

M Aziz, A Jacob, A Matsuda, P Wang - Apoptosis, 2011 - Springer
Although the cloning and molecular characterization of MFG-E8 was first reported in the
early 90s, breakthrough on MFG-E8 research came into light when it was explored as an …