Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Pulmonary fibrosis is a pathologic process associated with scarring of the lung interstitium.
Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a …

Background Idiopathic pulmonary fibrosis (IPF) bears high mortality due to unclear
pathogenesis and limited therapeutic options. Therefore, identifying novel regulators is …

Simple Summary Cisplatin is a chemotherapy drug widely used in the treatment of different
cancer types. However, cisplatin displays a high range of toxicity and its use usually leads to …

Colorectal cancer (CRC) develops in part through the deregulation of different signaling
pathways, including activation of the WNT/β-catenin and PI3K/AKT pathways. Additionally …

We have previously established a novel mouse model of lung fibrosis based on Adeno-
associated virus (AAV)-mediated pulmonary overexpression of TGFβ1. Here, we provide an …

Aberrant lung cell differentiation is a hallmark of many lung diseases including chronic
obstructive pulmonary disease (COPD). The EZH2-containing Polycomb Repressive …

Fibrosis, or excessive scarring, is characterized by the emergence of alpha-smooth muscle
actin (αSMA)-expressing myofibroblasts and the excessive accumulation of fibrotic …

Structural analysis of tazemetostat, an FDA-approved EZH2 inhibitor, led us to pinpoint a
suitable site for appendage with a pharmacophoric fragment of second-generation HSP90 …

Early-life (EL) respiratory infections increase pulmonary disease risk, especially EL-
Respiratory Syncytial Virus (EL-RSV) infections linked to asthma. Mechanisms underlying …