B-type lamins are fundamental components of the nuclear lamina, a complex structure that
acts as a scaffold for organization and function of the nucleus. Lamin B1 and B2, the most …

Lamin B1 is an essential protein of the nuclear lamina that plays a crucial role in nuclear
function and organization. It has been demonstrated that lamin B1 is essential for …

Autosomal dominant leukodystrophy (ADLD) is an ultra-rare, slowly progressive, and fatal
neurodegenerative disorder associated with the loss of white matter in the central nervous …

Phosphoinositide-specific phospholipases C (PI-PLCs) are a class of enzymes involved in
the phosphatidylinositol metabolism, which is implicated in the activation of several …

Leukodystrophies are a broad spectrum of neurological disorders that are characterized
primarily by deficiencies in myelin formation. Clinical manifestations of leukodystrophies …

In the last three decades, the presence of phospholipids in the nucleus has been shown and
thoroughly investigated. A considerable amount of interest has been raised about nuclear …

Autosomal dominant leukodystrophy (ADLD) is an extremely rare and fatal
neurodegenerative disease due to the overexpression of the nuclear lamina component …

Objectives We aimed to elucidate the pathogenic mechanisms underlying autosomal
dominant adult‐onset demyelinating leukodystrophy (ADLD), and to understand the …

The nuclear envelope compartmentalizes the nuclear DNA from the cytoplasm and protects,
organizes, and regulates the eukaryote genome while adapting to its environment, including …

Inherited white matter disorders include a wide range of disorders of various origins with
distinct genetic, pathophysiologic, and metabolic backgrounds. Although most of these …