The tumor microenvironment in tumorigenesis and therapy resistance revisited

K Dzobo, DA Senthebane, C Dandara - Cancers, 2023 - mdpi.com
Simple Summary Tumors are not masses of cancer cells alone but made up of cancer cells,
other cells including fibroblasts, macrophages, endothelial cells, as well as secreted factors …

[HTML][HTML] The impact of histone deacetylase inhibitors on immune cells and implications for cancer therapy

B Moran, M Davern, JV Reynolds, NE Donlon… - Cancer Letters, 2023 - Elsevier
Many cancers possess the ability to suppress the immune response to malignant cells, thus
facilitating tumour growth and invasion, and this has fuelled research to reverse these …

B-cell-specific checkpoint molecules that regulate anti-tumour immunity

L Bod, YC Kye, J Shi, E Torlai Triglia, A Schnell… - Nature, 2023 - nature.com
The role of B cells in anti-tumour immunity is still debated and, accordingly,
immunotherapies have focused on targeting T and natural killer cells to inhibit tumour …

CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

X Lei, DC de Groot, MJP Welters, T de Wit… - Cellular & molecular …, 2024 - nature.com
CD4+ T cells can" help” or" license” conventional type 1 dendritic cells (cDC1s) to induce
CD8+ cytotoxic T lymphocyte (CTL) anticancer responses, as proven in mouse models. We …

TimiGP: Inferring cell-cell interactions and prognostic associations in the tumor immune microenvironment through gene pairs

C Li, B Zhang, E Schaafsma, A Reuben, L Wang… - Cell Reports …, 2023 - cell.com
Determining the prognostic association of different immune cell types in the tumor
microenvironment is critical for understanding cancer biology and developing new …

Clinical significance of tumor-infiltrating conventional and plasmacytoid dendritic cells in pancreatic ductal adenocarcinoma

I Plesca, I Benešová, C Beer, U Sommer, L Mueller… - Cancers, 2022 - mdpi.com
Simple Summary The tumor immune contexture plays a pivotal role for the clinical outcome
of cancer patients and the efficacy of various treatment modalities. Dendritic cells (DCs) …

Interleukins and interferons in mesenchymal stromal stem cell-based gene therapy of cancer

U Švajger, U Kamenšek - Cytokine & Growth Factor Reviews, 2024 - Elsevier
The tumor microenvironment is importantly shaped by various cytokines, where interleukins
(ILs) and interferons (IFNs) shape the balance of immune activity within tumor niche and …

Flt3L therapy increases the abundance of Treg-promoting CCR7+ cDCs in preclinical cancer models

EJ Clappaert, D Kancheva, J Brughmans… - Frontiers in …, 2023 - frontiersin.org
Conventional dendritic cells (cDCs) are at the forefront of activating the immune system to
mount an anti-tumor immune response. Flt3L is a cytokine required for DC development that …

The role of immune modulatory cytokines in the tumor microenvironments of head and neck squamous cell carcinomas

N Kondoh, M Mizuno-Kamiya - Cancers, 2022 - mdpi.com
Simple Summary Malignant phenotypes of head and neck squamous cell carcinomas
(HNSCCs) are regulated by the pro-and anti-tumoral activities of immune modulatory …

Comprehensive analyses of ferroptosis-related alterations and their prognostic significance in glioblastoma

Y Tian, H Liu, C Zhang, W Liu, T Wu, X Yang… - Frontiers in Molecular …, 2022 - frontiersin.org
Background: This study was designed to explore the implications of ferroptosis-related
alterations in glioblastoma patients. Method: After obtaining the data sets CGGA325 …