The tumor microenvironment in tumorigenesis and therapy resistance revisited
Simple Summary Tumors are not masses of cancer cells alone but made up of cancer cells,
other cells including fibroblasts, macrophages, endothelial cells, as well as secreted factors …
other cells including fibroblasts, macrophages, endothelial cells, as well as secreted factors …
[HTML][HTML] The impact of histone deacetylase inhibitors on immune cells and implications for cancer therapy
Many cancers possess the ability to suppress the immune response to malignant cells, thus
facilitating tumour growth and invasion, and this has fuelled research to reverse these …
facilitating tumour growth and invasion, and this has fuelled research to reverse these …
B-cell-specific checkpoint molecules that regulate anti-tumour immunity
The role of B cells in anti-tumour immunity is still debated and, accordingly,
immunotherapies have focused on targeting T and natural killer cells to inhibit tumour …
immunotherapies have focused on targeting T and natural killer cells to inhibit tumour …
CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors
X Lei, DC de Groot, MJP Welters, T de Wit… - Cellular & molecular …, 2024 - nature.com
CD4+ T cells can" help” or" license” conventional type 1 dendritic cells (cDC1s) to induce
CD8+ cytotoxic T lymphocyte (CTL) anticancer responses, as proven in mouse models. We …
CD8+ cytotoxic T lymphocyte (CTL) anticancer responses, as proven in mouse models. We …
TimiGP: Inferring cell-cell interactions and prognostic associations in the tumor immune microenvironment through gene pairs
Determining the prognostic association of different immune cell types in the tumor
microenvironment is critical for understanding cancer biology and developing new …
microenvironment is critical for understanding cancer biology and developing new …
Clinical significance of tumor-infiltrating conventional and plasmacytoid dendritic cells in pancreatic ductal adenocarcinoma
I Plesca, I Benešová, C Beer, U Sommer, L Mueller… - Cancers, 2022 - mdpi.com
Simple Summary The tumor immune contexture plays a pivotal role for the clinical outcome
of cancer patients and the efficacy of various treatment modalities. Dendritic cells (DCs) …
of cancer patients and the efficacy of various treatment modalities. Dendritic cells (DCs) …
Interleukins and interferons in mesenchymal stromal stem cell-based gene therapy of cancer
U Švajger, U Kamenšek - Cytokine & Growth Factor Reviews, 2024 - Elsevier
The tumor microenvironment is importantly shaped by various cytokines, where interleukins
(ILs) and interferons (IFNs) shape the balance of immune activity within tumor niche and …
(ILs) and interferons (IFNs) shape the balance of immune activity within tumor niche and …
Flt3L therapy increases the abundance of Treg-promoting CCR7+ cDCs in preclinical cancer models
EJ Clappaert, D Kancheva, J Brughmans… - Frontiers in …, 2023 - frontiersin.org
Conventional dendritic cells (cDCs) are at the forefront of activating the immune system to
mount an anti-tumor immune response. Flt3L is a cytokine required for DC development that …
mount an anti-tumor immune response. Flt3L is a cytokine required for DC development that …
The role of immune modulatory cytokines in the tumor microenvironments of head and neck squamous cell carcinomas
N Kondoh, M Mizuno-Kamiya - Cancers, 2022 - mdpi.com
Simple Summary Malignant phenotypes of head and neck squamous cell carcinomas
(HNSCCs) are regulated by the pro-and anti-tumoral activities of immune modulatory …
(HNSCCs) are regulated by the pro-and anti-tumoral activities of immune modulatory …
Comprehensive analyses of ferroptosis-related alterations and their prognostic significance in glioblastoma
Y Tian, H Liu, C Zhang, W Liu, T Wu, X Yang… - Frontiers in Molecular …, 2022 - frontiersin.org
Background: This study was designed to explore the implications of ferroptosis-related
alterations in glioblastoma patients. Method: After obtaining the data sets CGGA325 …
alterations in glioblastoma patients. Method: After obtaining the data sets CGGA325 …