Background Atopic dermatitis (AD) is a chronic inflammatory disease caused by the complex
interaction of genetic, immune and environmental factors. There have many recent …

The Th2 immune response, culminating in eosinophilia and IgE production, is not only
characteristic of allergy but also of infection by parasitic worms (helminths). Anti-parasite IgE …

Atopic dermatitis (AD) is a multifactorial inflammatory skin disease resulting from interactions
between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly …

Glucocorticoid‐induced tumour necrosis factor receptor‐related protein (GITR, TNFRSF18,
and CD357) is expressed at high levels in activated T cells and regulatory T cells (Tregs). In …

The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …

Systemic therapy for atopic dermatitis (AD) is indicated in patients with severe disease
refractory to adequate topical treatment. Currently available drugs aim to decrease …

Allergic diseases [asthma, rhinitis and atopic dermatitis (AD)] are complex. They are
associated with allergen‐specific IgE and nonallergic mechanisms that may coexist in the …

Abstract Regulatory FOXP3+ T cells (Tregs) constitute 5% to 10% of T cells in the normal
human skin. They play an important role in the induction and maintenance of immunological …

Objective To determine whether IL-4, IL-4Rα and STAT6 polymorphisms are associated with
susceptibility to dermatitis in Egyptian children. Methods We genotyped three groups of …

Increasing evidence shows that human exposure to bisphenols can increase the risk of
allergic disease, such as child asthma. However, the mechanism by which exposure to …