Cell migration is a highly dynamic process driven by the cytoskeleton, which mainly
comprises the actin microfilaments, microtubules, and intermediate filaments. During …

Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …

Vimentin is a protein that has been linked to a large variety of pathophysiological conditions,
including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also …

The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …

Metastasis is responsible for the greatest number of cancer deaths. Metastatic disease, or
the movement of cancer cells from one site to another, is a complex process requiring …

Thoracic aortic aneurysm is a potentially life-threatening condition in that it places patients at
risk for aortic dissection or rupture. However, our modern understanding of the pathogenesis …

Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in
1975. Thirty five years of FLNa research has revealed its structure in great detail, discovered …

Cell shape and mechanics are determined by the interplay of three distinct cytoskeletal
networks, made of actin filaments, microtubules, and intermediate filaments. These three …

From the extracellular matrix to the cytoskeleton, a network of molecular links connects cells
to their environment. Molecules in this network transmit and detect mechanical forces, which …

Vimentin intermediate filaments (VIF) extend throughout the rear and perinuclear regions of
migrating fibroblasts, but only nonfilamentous vimentin particles are present in lamellipodial …