The vascular depression hypothesis: mechanisms linking vascular disease with depression

WD Taylor, HJ Aizenstein, GS Alexopoulos - Molecular psychiatry, 2013 - nature.com
Abstract The 'Vascular Depression'hypothesis posits that cerebrovascular disease may
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …

Obstructive sleep apnea is linked to depression and cognitive impairment: evidence and potential mechanisms

NA Kerner, SP Roose - The American Journal of Geriatric Psychiatry, 2016 - Elsevier
Obstructive sleep apnea (OSA) is highly prevalent but very frequently undiagnosed. OSA is
an independent risk factor for depression and cognitive impairment/dementia. Herein the …

Age differences in the prevalence and co‐morbidity of DSM‐IV major depressive episodes: results from the WHO World Mental Health Survey Initiative

RC Kessler, HG Birnbaum, V Shahly… - Depression and …, 2010 - Wiley Online Library
Background: Although depression appears to decrease in late life, this could be due to
misattribution of depressive symptoms to physical disorders that increase in late life …

Vascular depression consensus report–a critical update

HJ Aizenstein, A Baskys, M Boldrini, MA Butters… - BMC medicine, 2016 - Springer
Background Vascular depression is regarded as a subtype of late-life depression
characterized by a distinct clinical presentation and an association with cerebrovascular …

The emotion paradox in the aging brain

M Mather - Annals of the New York Academy of Sciences, 2012 - Wiley Online Library
This paper reviews age differences in emotion processing and how they may relate to age‐
related changes in the brain. Compared with younger adults, older adults react less to …

Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide

J Savitz, WC Drevets - Neuroscience & Biobehavioral Reviews, 2009 - Elsevier
Both major depressive disorder and bipolar disorder are the subject of a voluminous
imaging and genetics literature. Here, we attempt a comprehensive review of MRI and …

The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological features

SL Naismith, LM Norrie, L Mowszowski… - Progress in neurobiology, 2012 - Elsevier
As the population ages, the economic and societal impacts of neurodegenerative and
neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive …

Differential relationships between apathy and depression with white matter microstructural changes and functional outcomes

MJ Hollocks, AJ Lawrence, RL Brookes, TR Barrick… - Brain, 2015 - academic.oup.com
Small vessel disease is a stroke subtype characterized by pathology of the small perforating
arteries, which supply the sub-cortical structures of the brain. Small vessel disease is …

Risk factors for poststroke depression: identification of inconsistencies based on a systematic review

A De Ryck, R Brouns, M Geurden… - Journal of geriatric …, 2014 - journals.sagepub.com
Objective: Depression after stroke or poststroke depression (PSD) has a negative impact on
the rehabilitation process and the associated rehabilitation outcome. Consequently, defining …

Imaging phenotypes of major depressive disorder: genetic correlates

JB Savitz, WC Drevets - Neuroscience, 2009 - Elsevier
Imaging techniques are a potentially powerful method of identifying phenotypes that are
associated with, or are indicative of, a vulnerability to developing major depressive disorder …