MRI methods are widely used to follow the pathological evolution of multiple sclerosis in life
and its modification by treatment. To date, measures of the number and volume of …

Visual impairment is a key manifestation of multiple sclerosis. Acute optic neuritis is a
common, often presenting manifestation, but visual deficits and structural loss of retinal …

Axonal loss is thought to be a likely cause of persistent disability after a multiple sclerosis
relapse; therefore, noninvasive in vivo markers specific for axonal loss are needed. We used …

Owing to its ability to depict the pathologic features of multiple sclerosis (MS) in exquisite
detail, conventional magnetic resonance (MR) imaging has become an established tool in …

Gray matter (GM) involvement is detected even in the earliest stages of multiple sclerosis
(MS), and GM atrophy occurs at a faster rate than white matter (WM) atrophy early in the …

Optic neuritis is a common condition that causes reversible loss of vision. It can be clinically
isolated or can arise as one of the manifestations of multiple sclerosis. Occasional cases are …

Multiple sclerosis (MS) is a neurological disorder affecting the central nervous system and
features extensive functional brain changes that are poorly understood but relate strongly to …

Vision loss after retinal or cerebral visual injury (CVI) was long considered to be irreversible.
However, there is considerable potential for vision restoration and recovery even in …

The development of therapeutic strategies that promote functional recovery is a major goal
of multiple sclerosis (MS) research. Neuroscientific and methodological advances have …

Magnetic resonance (MR) techniques are of value in following the pathological process of
multiple sclerosis in vivo. They are widely applied to monitor the disease natural history and …