Uterine luminal epithelium as the transient gateway for embryo implantation

X Ye - Trends in Endocrinology & Metabolism, 2020 - cell.com
The uterine luminal epithelium (LE) is the first maternal contact for an implanting embryo.
Intrauterine fluid resorption, cessation of LE proliferation and apoptosis, and LE structural …

The role of LGR4 (GPR48) in normal and cancer processes

A Ordaz-Ramos, VH Rosales-Gallegos… - International journal of …, 2021 - mdpi.com
Leucine-rich repeats containing G protein-coupled receptor 4 (LGR4) is a receptor that
belongs to the superfamily of G protein-coupled receptors that can be activated by R …

Uterine aquaporin expression is dynamically regulated by estradiol and progesterone and ovarian stimulation disrupts embryo implantation without affecting luminal …

V De Oliveira, J Schaefer, B Abu-Rafea… - Molecular human …, 2020 - academic.oup.com
The study investigated the effect of normal and supraphysiological (resulting from
gonadotropin-dependent ovarian stimulation) levels of estradiol (E2) and progesterone (P4) …

Uterine kisspeptin receptor critically regulates epithelial estrogen receptor α transcriptional activity at the time of embryo implantation in a mouse model

J Schaefer, AG Vilos, GA Vilos… - Molecular human …, 2021 - academic.oup.com
Embryo implantation failure is a major cause of infertility in women of reproductive age and a
better understanding of uterine factors that regulate implantation is required for developing …

Disruption of fertility, placenta, pregnancy outcome, and multigenerational inheritance of hepatic steatosis by organotin exposure from contaminated seafood in rats

PL Podratz, E Merlo, JFP de Araújo, JGM Ayub… - Science of the Total …, 2020 - Elsevier
Early life exposure to endocrine-disrupting chemicals (EDCs) is an emerging risk factor for
development of complications later in life and in subsequent generations. We previously …

MEKK4-mediated Phosphorylation of HOXA10 at Threonine 362 facilitates embryo adhesion to the endometrial epithelium

M Zhang, Q Zhang, Z Cao, X Cai, J Liu, Y Jiang… - Cell Death …, 2022 - nature.com
Embryo adhesion is a very important step in the embryo implantation process. Homeobox
A10 (HOXA10), a key transcriptional factor of endometrial receptivity, is indispensable for …

[HTML][HTML] Time-Restricted Feeding Ameliorates Uterine Epithelial Estrogen Receptor α Transcriptional Activity at the Time of Embryo Implantation in Mice Fed a High …

L Liu, Y Zhuo, H Zhang, J Li, X Jiang, X Han… - The Journal of …, 2023 - Elsevier
Background More than 30% of reproductive-age women are obese or overweight. Obesity
and exposure to a high-fat diet (HFD) detrimentally affect endometrial development and …

Prednisolone alters endometrial decidual cells and affects decidual-trophoblast interactions

E Grbac, T So, S Varshney, N Williamson… - Frontiers in Cell and …, 2021 - frontiersin.org
Poor pregnancy outcomes such as recurrent pregnancy loss (RPL) and preeclampsia are
associated with impaired decidualization and abnormal trophoblast invasion. Emerging …

Uterine Gpr83 mRNA is highly expressed during early pregnancy and GPR83 mediates the actions of PEN in endometrial and non-endometrial cells

N Parobchak, S Rao, A Negron, J Schaefer… - F&S Science, 2020 - Elsevier
Objective To characterize the expression and signaling of uterine GPR83 in vivo in the
nonpregnant and pregnant mouse and in vitro in human endometrial and nonendometrial …

Emerging roles for LGR4 in organ development, energy metabolism and carcinogenesis

L Yang, J Wang, X Gong, Q Fan, X Yang, Y Cui… - Frontiers in …, 2022 - frontiersin.org
The leucine-rich repeats containing G protein-coupled receptor 4 (LGR4) belonging to G
protein-coupled receptors (GPCRs) family, had various regulatory roles at multiple cellular …