Heparin, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has
numerous important biological activities, associated with its interaction with diverse proteins …

This review will summarize our current state of knowledge of the structure, biochemical
properties and functions of syndecans, a family of transmembrane heparan sulphate …

Midkine (MK) and pleiotrophin (PTN) are low molecular weight proteins with closely related
structures. They are mainly composed of two domains held by disulfide bridges, and there …

Pleiotrophin (PTN) is a platelet-derived growth factor-inducible, 18-kDa heparin-binding
cytokine that signals diverse phenotypes in normal and deregulated cellular growth and …

Publisher Summary This chapter discusses the structural aspects and structure–activity
relationships of heparin/heparan sulfate (HS). The molecular mechanism behind the …

Bone marrow (BM) perivascular stromal cells and vascular endothelial cells (ECs) are
essential for hematopoietic stem cell (HSC) maintenance, but the roles of distinct niche …

Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents
of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many …

Anchorage of cells to" heparin"–binding domains that are prevalent in extracellular matrix
(ECM) components is thought to occur primarily through the syndecans, a four-member …

The receptor tyrosine kinase product of the anaplastic lymphoma kinase (ALK) gene has
been implicated in oncogenesis as a product of several chromosomal translocations …

Alzheimer's disease (AD) is clinically characterized with progressive memory loss and
cognitive decline. Synaptic dysfunction is an early pathological feature that occurs prior to …