Drp1-dependent mitochondrial fission in cardiovascular disease
J Jin, X Wei, X Zhi, X Wang, D Meng - Acta Pharmacologica Sinica, 2021 - nature.com
Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to
modulate their morphology, distribution, and function, which are referred as 'mitochondrial …
modulate their morphology, distribution, and function, which are referred as 'mitochondrial …
[HTML][HTML] Mitochondria-associated endoplasmic reticulum membranes in cardiovascular diseases
P Gao, Z Yan, Z Zhu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
The endoplasmic reticulum (ER) and mitochondria are physically connected to form
dedicated structural domains known as mitochondria-associated ER membranes (MAMs) …
dedicated structural domains known as mitochondria-associated ER membranes (MAMs) …
Mitochondrial fission and fusion
H Lee, Y Yoon - Biochemical Society Transactions, 2016 - portlandpress.com
Mitochondrial fission and fusion have been recognized as critical processes in the health of
mitochondria and cells. Two decades of studies have generated a great deal of information …
mitochondria and cells. Two decades of studies have generated a great deal of information …
[HTML][HTML] LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation
X Wang, Q Li, S He, J Bai, C Ma, L Zhang, X Guan… - Molecular …, 2022 - Springer
Background Pyroptosis is a form of programmed cell death involved in the
pathophysiological progression of hypoxic pulmonary hypertension (HPH). Emerging …
pathophysiological progression of hypoxic pulmonary hypertension (HPH). Emerging …
Sarcoplasmic reticulum–mitochondria communication in cardiovascular pathophysiology
C Lopez-Crisosto, C Pennanen… - Nature Reviews …, 2017 - nature.com
Repetitive, calcium-mediated contractile activity renders cardiomyocytes critically dependent
on a sustained energy supply and adequate calcium buffering, both of which are provided …
on a sustained energy supply and adequate calcium buffering, both of which are provided …
The pyruvate dehydrogenase complex: Life's essential, vulnerable and druggable energy homeostat
PW Stacpoole, CE McCall - Mitochondrion, 2023 - Elsevier
Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …
Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension
KR Stenmark, MG Frid, BB Graham… - Cardiovascular …, 2018 - academic.oup.com
Pulmonary hypertension (PH) is the end result of interaction between pulmonary vascular
tone and a complex series of cellular and molecular events termed 'vascular remodelling' …
tone and a complex series of cellular and molecular events termed 'vascular remodelling' …
Mitochondrial dynamics and cell death in heart failure
J Marín-García, AT Akhmedov - Heart failure reviews, 2016 - Springer
The highly regulated processes of mitochondrial fusion (joining), fission (division) and
trafficking, collectively called mitochondrial dynamics, determine cell-type specific …
trafficking, collectively called mitochondrial dynamics, determine cell-type specific …
[HTML][HTML] Translational Advances in the Field of Pulmonary Hypertension.From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting …
Pulmonary arterial hypertension (PAH) has been frequently compared with a type of
malignant disease and has an incredible number of pathogenic mechanisms similar to …
malignant disease and has an incredible number of pathogenic mechanisms similar to …
PM2. 5 triggered apoptosis in lung epithelial cells through the mitochondrial apoptotic way mediated by a ROS-DRP1-mitochondrial fission axis
X Liu, X Zhao, X Li, S Lv, R Ma, Y Qi… - Journal of hazardous …, 2020 - Elsevier
Epidemiological studies revealed a sharp increase in respiratory diseases attributed to PM
2.5. However, the underlying mechanisms remain unclear. Evidence suggested …
2.5. However, the underlying mechanisms remain unclear. Evidence suggested …