Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to
modulate their morphology, distribution, and function, which are referred as 'mitochondrial …

The endoplasmic reticulum (ER) and mitochondria are physically connected to form
dedicated structural domains known as mitochondria-associated ER membranes (MAMs) …

Mitochondrial fission and fusion have been recognized as critical processes in the health of
mitochondria and cells. Two decades of studies have generated a great deal of information …

Background Pyroptosis is a form of programmed cell death involved in the
pathophysiological progression of hypoxic pulmonary hypertension (HPH). Emerging …

Repetitive, calcium-mediated contractile activity renders cardiomyocytes critically dependent
on a sustained energy supply and adequate calcium buffering, both of which are provided …

Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

Pulmonary hypertension (PH) is the end result of interaction between pulmonary vascular
tone and a complex series of cellular and molecular events termed 'vascular remodelling' …

The highly regulated processes of mitochondrial fusion (joining), fission (division) and
trafficking, collectively called mitochondrial dynamics, determine cell-type specific …

Pulmonary arterial hypertension (PAH) has been frequently compared with a type of
malignant disease and has an incredible number of pathogenic mechanisms similar to …

Epidemiological studies revealed a sharp increase in respiratory diseases attributed to PM
2.5. However, the underlying mechanisms remain unclear. Evidence suggested …