Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-
threatening. The continued emergence of antibiotic resistance, together with our increasing …

Recent advances in the analysis of microbial communities colonizing the human body have
identified a resident microbial community in the human urinary tract (UT). Compared to many …

Recent advances in preclinical modeling of urinary tract infections (UTIs) have enabled the
identification of key facets of the host response that influence pathogen clearance and tissue …

Previous urinary tract infections (UTIs) can predispose one to future infections; however, the
underlying mechanisms affecting recurrence are poorly understood. We previously found …

Urinary tract infections (UTIs) are among the most common infectious diseases worldwide
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …

Persisters are nongrowing, transiently antibiotic-tolerant bacteria within a clonal population
of otherwise susceptible cells. Their formation is triggered by environmental cues and …

The bladder is continuously protected by passive defences such as a mucus layer,
antimicrobial peptides and secretory immunoglobulins; however, these defences are …

Emerging and re-emerging bacterial infections are a serious threat to human and animal
health. Extracellular bacteria are free-living, while facultative intracellular bacteria replicate …

Urinary tract infections (UTIs) are caused by uropathogenic Escherichia coli (UPEC) strains.
In contrast to many enteric E. coli pathogroups, no genetic signature has been identified for …

Urinary tract infections (UTIs) cause a substantial health care burden. UTIs (i) are most often
caused by uropathogenic Escherichia coli (UPEC),(ii) primarily affect otherwise healthy …