The emerging treatment landscape of targeted therapy in non-small-cell lung cancer

M Yuan, LL Huang, JH Chen, J Wu, Q Xu - Signal transduction and …, 2019 - nature.com
Lung cancer is one of the most common cancer in the world. In 2018, there were over 2
million new cases of lung cancer and over 1.7 million deaths were attributed to lung cancer …

Cell death-based treatment of lung adenocarcinoma

TV Denisenko, IN Budkevich, B Zhivotovsky - Cell death & disease, 2018 - nature.com
The most common type of lung cancer is adenocarcinoma (ADC), comprising around 40% of
all lung cancer cases. In spite of achievements in understanding the pathogenesis of this …

Lung cancer: current therapies and new targeted treatments

FR Hirsch, GV Scagliotti, JL Mulshine, R Kwon… - The Lancet, 2017 - thelancet.com
Lung cancer is the most frequent cause of cancer-related deaths worldwide. Every year, 1· 8
million people are diagnosed with lung cancer, and 1· 6 million people die as a result of the …

New and emerging targeted treatments in advanced non-small-cell lung cancer

FR Hirsch, K Suda, J Wiens, PA Bunn - The Lancet, 2016 - thelancet.com
Targeted therapies are substantially changing the management of lung cancers. These
treatments include drugs that target driver mutations, those that target presumed important …

TPGS‐functionalized polydopamine‐modified mesoporous silica as drug nanocarriers for enhanced lung cancer chemotherapy against multidrug resistance

W Cheng, C Liang, L Xu, G Liu, N Gao, W Tao, L Luo… - Small, 2017 - Wiley Online Library
A nanocarrier system of d‐a‐tocopheryl polyethylene glycol 1000 succinate (TPGS)‐
functionalized polydopamine‐coated mesoporous silica nanoparticles (NPs) is developed …

The resistance mechanisms and treatment strategies for ALK-rearranged non-small cell lung cancer

Y Pan, C Deng, Z Qiu, C Cao, F Wu - Frontiers in oncology, 2021 - frontiersin.org
Anaplastic lymphoma kinase (ALK) is a validated molecular target for non-small-cell lung
cancer (NSCLC). The use of tyrosine kinase inhibitors (TKIs) has led to significantly …

Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer

K Long, L Gu, L Li, Z Zhang, E Li, Y Zhang, L He… - Cell death & …, 2021 - nature.com
Abstract Apurinic/apyrimidinic endonuclease 1 (APE1) plays a critical role in the base
excision repair (BER) pathway, which is responsible for the excision of apurinic sites (AP …

Epidemiological trends of tracheal, bronchus, and lung cancer at the global, regional, and national levels: a population-based study

Y Deng, P Zhao, L Zhou, D Xiang, J Hu, Y Liu… - Journal of hematology & …, 2020 - Springer
Background Investigations of disease incidence, mortality, and disability-adjusted life years
(DALYs) are valuable for facilitating preventive measures and health resource planning. We …

[HTML][HTML] The evolution of master protocol clinical trial designs: a systematic literature review

EL Meyer, P Mesenbrink, C Dunger-Baldauf… - Clinical Therapeutics, 2020 - Elsevier
Purpose Recent years have seen a change in the way that clinical trials are being
conducted. There has been a rise of designs more flexible than traditional adaptive and …

Emerging therapies for non-small cell lung cancer

C Zhang, NB Leighl, YL Wu, WZ Zhong - Journal of hematology & oncology, 2019 - Springer
Recent advances in the field of novel anticancer agents prolong patients' survival and show
a promising future. Tyrosine kinase inhibitors and immunotherapy for lung cancer are the …