Intercellular communication mediated by cytokines is the main mechanism by which cells of
the immune system talk to each other. Many aspects of cytokine signalling in the immune …

Natural killer (NK) cells are effective in combating infections and tumors and as such are
tempting for adoptive transfer therapy. However, they are not homogeneous but can be …

Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain
angiogenesis and evade immune surveillance. STAT proteins—especially STAT3 and …

The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3)
is activated constitutively in a wide array of human cancers. It is an appealing molecular …

The signal transducers and activators of transcription (STAT) factors function as downstream
effectors of cytokine and growth factor receptor signaling. Compared with normal cells and …

Constitutive activation of signal transducer and activator of transcription (STAT) proteins has
been detected in a wide variety of human primary tumor specimens and tumor cell lines …

Abstract Signal Transducers and Activators of Transcription (STATs) are a family of
cytoplasmic proteins with roles as signal messengers and transcription factors that …

Simple Summary The Ras-Raf-MEK-ERK signaling pathway is responsible for regulating
cell proliferation, differentiation, and survival. Overexpression and overactivation of …

Cytoplasmic Janus protein tyrosine kinases (JAKs) are crucial components of diverse signal
transduction pathways that govern cellular survival, proliferation, differentiation and …

The colony-stimulating factors (CSFs) are a group of cytokines central to the hematopoiesis
of blood cells, the modulation of their functional responses, as well as the maintenance of …