Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …

Synaptic loss is a pathological feature of all neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of …

Objective Synaptic loss is an early feature of neurodegenerative disease models, and is
severe in post mortem clinical studies, including frontotemporal dementia. Positron emission …

PET technology has produced many radiopharmaceuticals that target specific brain proteins
and other measures of brain function. Recently, a new approach has emerged to image …

Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of upper and lower
motor neurons. In 10% of patients, the disorder runs in the family. Our aim was to study the …

Background Synaptic loss is characteristic of many neurodegenerative diseases; it occurs
early and is strongly related to functional deficits. Objective In this longitudinal observational …

With the increase in large multimodal cohorts and high‐throughput technologies, the
potential for discovering novel biomarkers is no longer limited by data set size. Artificial …

Background The characterisation of presymptomatic disease-burden patterns in
asymptomatic mutation carriers has a dual academic and clinical relevance. The …

Background Frontotemporal dementia (FTD) phenotypes are classically associated with
distinctive cortical atrophy patterns and regional hypometabolism. However, the spectrum of …