Genomic analyses in cancer have been enormously impactful, leading to the identification of
driver mutations and development of targeted therapies. But the functions of the vast majority …

Cancer biomarkers have transformed current practices in the oncology clinic. Continued
discovery and validation are crucial for improving early diagnosis, risk stratification, and …

Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal
neoplasms of the hindbrain with strong links to early development of the hindbrain 1, 2, 3, 4 …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …

In 2012, an international consensus paper reported that medulloblastoma comprises four
molecular subgroups (WNT, SHH, Group 3, and Group 4), each associated with distinct …

Cancer genomics has revealed many genes and core molecular processes that contribute to
human malignancies, but the genetic and molecular bases of many rare cancers remains …

ERBB4 (HER4) is a member of the ERBB family of receptor tyrosine kinases, a family that
includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 (Neu/HER2) …

Pediatric central nervous system tumors are the most common solid malignancies in
childhood, and aggressive therapy often leads to long-term sequelae in survivors, making …

Independent component analysis (ICA) is a matrix factorization approach where the signals
captured by each individual matrix factors are optimized to become as mutually independent …