Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design

G Bahr, LJ Gonzalez, AJ Vila - Chemical Reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

[HTML][HTML] Recent developments in the medicinal chemistry of single boron atom-containing compounds

S Song, P Gao, L Sun, D Kang, J Kongsted… - … Pharmaceutica Sinica B, 2021 - Elsevier
Various boron-containing drugs have been approved for clinical use over the past two
decades, and more are currently in clinical trials. The increasing interest in boron-containing …

Unveiling extreme photoreduction potentials of donor–acceptor cyanoarenes to access aryl radicals from aryl chlorides

J Xu, J Cao, X Wu, H Wang, X Yang… - Journal of the …, 2021 - ACS Publications
Since the seminal work of Zhang in 2016, donor–acceptor cyanoarene-based fluorophores,
such as 1, 2, 3, 5-tetrakis (carbazol-9-yl)-4, 6-dicyanobenzene (4CzIPN), have been widely …

Metallo-β-lactamase inhibitors inspired on snapshots from the catalytic mechanism

AR Palacios, MA Rossi, GS Mahler, AJ Vila - Biomolecules, 2020 - mdpi.com
β-Lactam antibiotics are the most widely prescribed antibacterial drugs due to their low
toxicity and broad spectrum. Their action is counteracted by different resistance mechanisms …

The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology

RJ Grams, WL Santos, IR Scorei… - Chemical …, 2024 - ACS Publications
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

Amino acid based antimicrobial agents–synthesis and properties

MG Nowak, AS Skwarecki, MJ Milewska - ChemMedChem, 2021 - Wiley Online Library
Structures of several dozen of known antibacterial, antifungal or antiprotozoal agents are
based on the amino acid scaffold. In most of them, the amino acid skeleton is of a crucial …

Structure and mechanism-guided design of dual serine/metallo-carbapenemase inhibitors

C Chen, P Oelschlaeger, D Wang, H Xu… - Journal of Medicinal …, 2022 - ACS Publications
Serine/metallo-carbapenemase-coproducing pathogens, often referred to as “superbugs”,
are a significant clinical problem. They hydrolyze nearly all available β-lactam antibiotics …

Principles and current strategies targeting metallo‐β‐lactamase mediated antibacterial resistance

YH Yan, G Li, GB Li - Medicinal Research Reviews, 2020 - Wiley Online Library
Resistance to β‐lactam antibacterials is commonly associated with the production of the
serine β‐lactamases (SBLs) and/or metallo‐β‐lactamases (MBLs). Although clinically useful …

Recent advances in β-lactamase inhibitor chemotypes and inhibition modes

R Li, X Chen, C Zhou, QQ Dai, L Yang - European journal of medicinal …, 2022 - Elsevier
The effectiveness of β-lactam antibiotics is increasingly influenced by serine β-lactamases
(SBLs) and metallo-β-lactamases (MBLs), which can hydrolyze β-lactam antibiotics. The …

Efforts towards the inhibitor design for New Delhi metallo-beta-lactamase (NDM-1)

KCN Venkata, M Ellebrecht, SK Tripathi - European journal of medicinal …, 2021 - Elsevier
Antimicrobial stewardship is imperative when treating bacterial infections because the
misuse and overuse of antibiotics have caused pathogens to develop life-threatening …