[HTML][HTML] Cortisol and development of depression in adolescence and young adulthood–a systematic review and meta-analysis
Z Zajkowska, N Gullett, A Walsh, V Zonca… - …, 2022 - Elsevier
Introduction Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been
implicated in the development of major depressive disorder (MDD) in adulthood. Less work …
implicated in the development of major depressive disorder (MDD) in adulthood. Less work …
Inflammation, lifestyle factors, and the microbiome‐gut‐brain Axis: relevance to depression and antidepressant action
Depression is considered a major public health concern, where existing pharmacological
treatments are not equally effective across all patients. The pathogenesis of depression …
treatments are not equally effective across all patients. The pathogenesis of depression …
Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions
Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …
public health implications. A consensus definition of TRD with demonstrated predictive utility …
[HTML][HTML] Microbiota-immune-brain interactions: A lifespan perspective
There is growing appreciation of key roles of the gut microbiota in maintaining homeostasis
and influencing brain and behaviour at critical windows across the lifespan. Mounting …
and influencing brain and behaviour at critical windows across the lifespan. Mounting …
Neuroinflammation and the kynurenine pathway in CNS disease: molecular mechanisms and therapeutic implications
Diseases of the central nervous system (CNS) remain a significant health, social and
economic problem around the globe. The development of therapeutic strategies for CNS …
economic problem around the globe. The development of therapeutic strategies for CNS …
Novel drug developmental strategies for treatment‐resistant depression
Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …
therapies are ineffective in many patients, novel strategies are needed to overcome …
Obesity and psychological distress
The relationship between high body weight and mental health has been studied for several
decades. Improvements in the quality of epidemiological, mechanistic and psychological …
decades. Improvements in the quality of epidemiological, mechanistic and psychological …
Major depressive disorder as a neuro-immune disorder: Origin, mechanisms, and therapeutic opportunities
Notwithstanding advances in understanding the pathophysiology of major depressive
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …
disorder (MDD), no single mechanism can explain all facets of this disorder. An expanding …
Burning down the house: reinventing drug discovery in psychiatry for the development of targeted therapies
AH Miller, CL Raison - Molecular Psychiatry, 2023 - nature.com
Despite advances in neuroscience, limited progress has been made in developing new and
better medications for psychiatric disorders. Available treatments in psychiatry rely on a few …
better medications for psychiatric disorders. Available treatments in psychiatry rely on a few …
Effect of minocycline on depressive symptoms in patients with treatment-resistant depression: a randomized clinical trial
J Hellmann-Regen, V Clemens, M Grözinger… - JAMA network …, 2022 - jamanetwork.com
Importance Insufficient treatment response and resulting chronicity constitute a major
problem in depressive disorders. Remission rates range as low as 15% to 40% and …
problem in depressive disorders. Remission rates range as low as 15% to 40% and …