ADAM-17: the enzyme that does it all
M Gooz - Critical reviews in biochemistry and molecular biology, 2010 - Taylor & Francis
This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor
necrosis factor converting enzyme (TACE), ADAM-17 has been reported to be an …
necrosis factor converting enzyme (TACE), ADAM-17 has been reported to be an …
Metalloproteases affecting blood coagulation, fibrinolysis and platelet aggregation from snake venoms: Definition and nomenclature of interaction sites
Snake venom metalloproteases, in addition to their contribution to the digestion of the prey,
affect various physiological functions by cleaving specific proteins. They exhibit their …
affect various physiological functions by cleaving specific proteins. They exhibit their …
From snake venom toxins to therapeutics–cardiovascular examples
Snakes have fascinated the imaginations of people since the dawn of civilization. Their
deadly venoms cause significant mortality and morbidity worldwide, and strike fear in most of …
deadly venoms cause significant mortality and morbidity worldwide, and strike fear in most of …
The Lectin Receptor Kinase LecRK-I.9 Is a Novel Phytophthora Resistance Component and a Potential Host Target for a RXLR Effector
K Bouwmeester, M de Sain, R Weide, A Gouget… - PLoS …, 2011 - journals.plos.org
In plants, an active defense against biotrophic pathogens is dependent on a functional
continuum between the cell wall (CW) and the plasma membrane (PM). It is thus anticipated …
continuum between the cell wall (CW) and the plasma membrane (PM). It is thus anticipated …
[HTML][HTML] Disintegrins from snake venoms and their applications in cancer research and therapy
JKA Macêdo, JW Fox… - Current protein & peptide …, 2015 - ncbi.nlm.nih.gov
Integrins regulate diverse functions in cancer pathology and in tumor cell development and
contribute to important processes such as cell shape, survival, proliferation, transcription …
contribute to important processes such as cell shape, survival, proliferation, transcription …
[HTML][HTML] Venom-based peptide therapy: Insights into anti-cancer mechanism
R Ma, R Mahadevappa, HF Kwok - Oncotarget, 2017 - ncbi.nlm.nih.gov
The 5-year relative survival rate of all types of cancer has increased significantly over the
past three decades partly due to the targeted therapy. However, still there are many targeted …
past three decades partly due to the targeted therapy. However, still there are many targeted …
Structure-function relationship of the disintegrin family: Sequence signature and integrin interaction
AA Vasconcelos, JC Estrada, V David… - Frontiers in molecular …, 2021 - frontiersin.org
Disintegrins are small cysteine-rich proteins found in a variety of snake venom. These
proteins selectively modulate integrin function, heterodimeric receptors involved in cell-cell …
proteins selectively modulate integrin function, heterodimeric receptors involved in cell-cell …
Snake venom toxins: Potential anticancer therapeutics
BC Offor, LA Piater - Journal of Applied Toxicology, 2024 - Wiley Online Library
Snake venom contains a cocktail of compounds dominated by proteins and peptides, which
make up the toxin. The toxin components of snake venom attack several targets in the …
make up the toxin. The toxin components of snake venom attack several targets in the …
Synthesis and tumor inhibitory activity of novel coumarin analogs targeting angiogenesis and apoptosis
A sequence of coumarin analogs 5a–j was obtained by multi step synthesis from hydroxy
benzophenones (1a–j). The in vitro antiproliferative effect of the title compounds was tested …
benzophenones (1a–j). The in vitro antiproliferative effect of the title compounds was tested …
Snake venom disintegrins update: Insights about new findings
Snake venom disintegrins are low molecular weight, non-enzymatic proteins rich in cysteine,
present in the venom of snakes from the families Viperidae, Crotalidae, Atractaspididae …
present in the venom of snakes from the families Viperidae, Crotalidae, Atractaspididae …